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Titolo:
Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study
Autore:
Berendse, HW; Verbunt, JPA; Scheltens, P; van Dijk, BW; Jonkman, EJ;
Indirizzi:
Free Univ Amsterdam Hosp, Res Inst Neurosci, Dept Neurol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands Free Univ Amsterdam Hosp, Res Inst Neurosci, Dept Clin Neurophysiol, Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands , Amsterdam, Netherlands Free Univ Amsterdam Hosp, MEG Ctr KNAW, Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands , Amsterdam, Netherlands
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 4, volume: 111, anno: 2000,
pagine: 604 - 612
SICI:
1388-2457(200004)111:4<604:MAOCAI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY DEGENERATIVE DEMENTIA; BRAIN ELECTRICAL-ACTIVITY; MILD SENILE DEMENTIA; QUANTITATIVE EEG; FUNCTIONAL CONNECTIVITY; MULTIINFARCT DEMENTIA; RECOGNITION MEMORY; MODERATE DEMENTIA; SPECTRAL-ANALYSIS; NORMAL ADULTS;
Keywords:
dementia; Alzheimer's disease; MEG; power; coherence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Berendse, HW Free Univ Amsterdam Hosp, Res Inst Neurosci, Dept Neurol, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
H.W. Berendse et al., "Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study", CLIN NEU, 111(4), 2000, pp. 604-612

Abstract

Objectives: In the present study, MEG was used to analyze spectral power and reference-free coherence in patients with probable Alzheimer's disease (AD). Methods: Sixty-one channel MEG was recorded in 5 AD patients and 5 age-matched controls at rest with eyes open and eyes closed, as well as during theperformance of two different mental tasks. Artefact-free epochs were selected for the analysis of power and coherence: values in each of 5 4-Hz wide frequency bands ranging from 2 to 22 Hz. Results: In AD patients, the absolute low frequency magnetic power was significantly and rather diffusely increased relative Co controls with a fronto-central maximum. High frequency power values were significantly decreasedover the occipital and temporal areas. Reactivity to eye-opening and mental tasks was reduced in the patient group. Relative to controls, a general decrease of MEC coherence values, including all frequencies analyzed, was found in AD patients. Conclusions: These observations confirm the pattern of changes in spectralpower and reactivity known from EEG studies and suggest that coherence decreases in AD patients are widespread and include frequencies outside the alpha band. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 05/04/20 alle ore 03:36:54