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Titolo:
Rheological properties of fetal red cells with special reference to aggregability and disaggregability analyzed by light transmission and laser backscattering techniques
Autore:
El Bouhmadi, A; Boulot, P; Laffargue, F; Brun, JF;
Indirizzi:
CHU Lapeyronie, Ctr Explorat & Readaptat Anomalies Metab Musculai, Serv Cent Physiol Clin, F-34295 Montpellier 5, France CHU Lapeyronie MontpellierFrance 5 Clin, F-34295 Montpellier 5, France Hop Arnaud de Villeneuve, Serv Gynecol Obstet, Montpellier, France Hop Arnaud de Villeneuve Montpellier France Obstet, Montpellier, France
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 2, volume: 22, anno: 2000,
pagine: 79 - 90
SICI:
1386-0291(2000)22:2<79:RPOFRC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE DEFORMABILITY; BLOOD-VISCOSITY; AGGREGATION; DELIVERY; NEWBORN; LABOR; FLOW;
Keywords:
fetal blood; cordocentesis; hemorheology; erythrocyte deformability; blood viscosity; erythrocyte aggregation; vascular resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Brun, JF CHU Lapeyronie, Ctr Explorat & Readaptat Anomalies Metab Musculai, Serv Cent Physiol Clin, F-34295 Montpellier 5, France CHU Lapeyronie Montpellier France 5 34295 Montpellier 5, France
Citazione:
A. El Bouhmadi et al., "Rheological properties of fetal red cells with special reference to aggregability and disaggregability analyzed by light transmission and laser backscattering techniques", CL HEMORH M, 22(2), 2000, pp. 79-90

Abstract

Blood viscosity factors and fetal erythrocyte aggregability were investigated with light transmission (Myrenne device) during a cross-sectional studyof blood drawn in utero by cord venepunctures in 119 normal fetuses between 18 and 39 weeks gestation. There was a progressive increased blood viscosity at native hematocrit (p<0.01) explained by a gradual increase in both hematocrit (from 33% to 40%, p<0.05) and Dintenfass' 'Tk' RBC rigidity index(p<0.05), while plasma viscosity remained constant at 1.18 +/- 0.01 mPa.s as well as the h/eta ratio (188.4 +/- 2.7 mPa(-1).s(-1)). The RBC aggregation index 'M' remained almost equal to zero (mean value: 0.04 +/- 0.01) before 32 wk gestation and then increased (p<0.05) until delivery. The upper physiological limit for this parameter before 32 wk (mean +/- 2 SD) is 0.18. The RBC aggregation index 'M1' remained constant during pregnancy at 2.98 +/- 0.26, i.e., the upper physiological limit for this parameter during the intrauterine life (mean +/- 2 SD) is 7.85. Both fibrinogen (r=0.479, p<0.05) and albumin (r=0.494, p<0.01) correlated with time so that the albumin/fibrinogen ratio remained stable. We then studied with the laser retrodiffusion technique the venous blood of 20 women (18-43 yr, 37-40 wk gestation) and the cord blood of their newborns at birth, comparing RBC aggregation of: mothers (M), maternal RBCs resuspended on newborn plasma (MF), newborn RBCsresuspended on maternal plasma (FM), and newborns (F). Aggregability is higher in M (RBC aggregation time M<MF<FM<F; p<0.01); RBC aggregation index at 10 s M>MF>FM>F; p<0.01), with in turn the symmetric inverse picture for the partial disaggregation threshold (M>MF=FM>F). Thus RBC disaggregability is higher in newborns, and suspensions on maternal and newborn plasma suggest that half of this difference in aggregability (and disaggregability) between fetal and adult blood results from plasma factors and another half from erythrocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:41:16