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Titolo:
Computed tomographic abnormalities in Mycobacterium avium complex lung disease include the mosaic pattern of reduced lung attenuation
Autore:
Maycher, B; OConnor, R; Long, R;
Indirizzi:
Univ Manitoba, Dept Radiol, Winnipeg, MB, Canada Univ Manitoba Winnipeg MB Canada toba, Dept Radiol, Winnipeg, MB, Canada British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada British ColumbiaCanc Agcy Vancouver BC Canada V5Z 4E6 BC V5Z 4E6, Canada Univ Alberta, Dept Med, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Alberta, Dept Med, Edmonton, AB, Canada
Titolo Testata:
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
fascicolo: 2, volume: 51, anno: 2000,
pagine: 93 - 102
SICI:
0846-5371(200004)51:2<93:CTAIMA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-RESOLUTION CT; PULMONARY TUBERCULOSIS; HYPERSENSITIVITY PNEUMONITIS; NONTUBERCULOUS MYCOBACTERIA; INTRACELLULARE COMPLEX; CLINICAL-SIGNIFICANCE; DIFFUSING-CAPACITY; INFECTION; BRONCHIECTASIS; EPIDEMIOLOGY;
Keywords:
bronchiectasis; lung diseases; mycobacterium avium complex; mycobacterium avium-intracellulare infection; tomography, x-ray computed;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Long, R Univ Alberta Hosp, Dept Med, Div Pulm Med, Walter Mackenzie Ctr 2E421, 8440 112 St, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp 8440 112 St Edmonton AB Canada T6G 2B7 7, Canada
Citazione:
B. Maycher et al., "Computed tomographic abnormalities in Mycobacterium avium complex lung disease include the mosaic pattern of reduced lung attenuation", CAN ASSOC R, 51(2), 2000, pp. 93-102

Abstract

Objective: To describe the range and frequency of abnormalities on computed tomographic (CT) scans in patients who met the American Thoracic Society (ATS) case definition of Mycobacterium avium complex (MAC) lung disease. Further, to report the effect of time and treatment on the progression of these abnormalities. Methods: The demographic, clinical and radiologic features of 10 patients with proven MAC lung disease (mean age 71 years, standard deviation 12 years) were described. The presence or absence of 14 CT abnormalities was recorded in each of 10 lung zones. The effects of time and treatment on the abnormalities were recorded. Results: The patients' lung function was minimally impaired. Pretreatment CT scans showed small nodules in 47% of the lung zones, reduced lung attenuation in 41%, and bronchiectasis in 27%. Bronchiectasis was associated with nodules in 20 zones from 9 patients and with no nodules in 7 zones from 1 patient. Reduced attenuation was associated with bronchiectasis alone in 8 zones, with nodules alone in 25 zones and with both bronchiectasis and nodules in 8 zones. In patients without treatment, or with non-curative treatment, bronchiectasis developed or worsened in 12 of 26 zones and resolved or improved in none. In contrast, after curative treatment, small nodules disappeared completely in 10 of 21 zones and developed in none. Of 7 zones with only nodules and reduced attenuation before treatment, 6 had no abnormalities after treatment. Conclusions: Our data suggest that the 3 leading CT abnormalities in nodular-bronchiectatic MAC lung disease are small nodules, reduced attenuation and bronchiectasis. Reduced attenuation appeared to result from gas trapping and hypoxic vasoconstriction due to bronchiolocentric inflammatory nodules. Bronchiectasis appeared to be secondary to this bronchiolar disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:54:20