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Titolo:
MK-801 blocks the development of sensitization to the locomotor effects ofmethylphenidate
Autore:
Gaytan, O; Nason, R; Alagugurusamy, R; Swann, A; Dafny, N;
Indirizzi:
Univ Texas, Sch Med, Dept Neurobiol & Anat, Houston, TX 77225 USA Univ Texas Houston TX USA 77225 t Neurobiol & Anat, Houston, TX 77225 USA Univ Texas, Sch Med, Dept Psychiat & Behav Sci, Houston, TX 77225 USA UnivTexas Houston TX USA 77225 ychiat & Behav Sci, Houston, TX 77225 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 51, anno: 2000,
pagine: 485 - 492
SICI:
0361-9230(200004)51:6<485:MBTDOS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; BEHAVIORAL SENSITIZATION; TIME-COURSE; AMPHETAMINE; COCAINE; MICE; METHAMPHETAMINE; RAT; DIZOCILPINE; INHIBITION;
Keywords:
methylphenidate; ritalin; MK-801; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Dafny, N Univ Texas, Sch Med, Dept Neurobiol & Anat, POB 20708, Houston, TX 77225 USA Univ Texas POB 20708 Houston TX USA 77225 , Houston, TX 77225 USA
Citazione:
O. Gaytan et al., "MK-801 blocks the development of sensitization to the locomotor effects ofmethylphenidate", BRAIN RES B, 51(6), 2000, pp. 485-492

Abstract

Male Sprague-Dawley rats were divided to three groups (each n = 8) and were housed in test cages where motor activity was recorded continuously for 16 days using a computerized motor activity monitoring system to determine whether repeated administration of MK-801 could block the development and/orthe expression of sensitization to the locomotor effects of methylphenidate (MPD), One group of rats received six daily injections (days 4-9) of 0.30mg/kg MK-801, followed by 5 days without injection (days 10-14) and re-challenged (day 15) with 0.30 mg/kg MK-801, The second group received a challenge dose of 2.5 mg/kg MPD (day 4) followed by 5 days of co-treatment with MK-801 (0.30 mg/kg) given 1 h prior to MPD (days 5-9), This group was then re-challenged with MPD (2.5 mg/kg) on day 15, The last group received six daily injections of 2.5 mg/kg MPD (days 4-9), They were then split into two subgroups of rats which received either no treatment (control) or five dailyinjections of 0.30 mg/kg MK-801 (days 10-14) before being re-challenged onday 15 with 2.5 mg/kg MPD. MK-801 sensitized to its own locomotor effects. MK-801 given after sensitization had developed (i.e., days 10-14) was ableto mask the expression of a sensitized response on day 15, but the effect was only transient since the sensitized response was present 3 weeks later. Moreover, MK-801, when coadministered during the repeated treatment phase was able to block the development of a sensitized response, which suggest that NMDA receptors involved in the process of MPD sensitization. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:09:26