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Titolo:
Leukotriene B-4 photoaffinity probes: Design, synthesis and evaluation of new arylazide-1,3-disubstituted cyclohexanes
Autore:
Durand, D; Hullot, P; Vidal, JP; Girard, JP; Baneres, JL; Parello, J; Muller, A; Bonne, C; Rossi, JC;
Indirizzi:
Fac Pharm Montpellier, UPRESA CNRS 5074, Lab Chim Biomol & Interact Biol, F-34060 Montpellier 2, France Fac Pharm Montpellier Montpellier France 2 F-34060 Montpellier 2, France
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 8, volume: 10, anno: 2000,
pagine: 811 - 814
SICI:
0960-894X(20000417)10:8<811:LBPPDS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHILS; CHEMOTAXIS; SUBSTANCE; POTENT; C-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Girard, JP Fac Pharm Montpellier, UPRESA CNRS 5074, Lab Chim Biomol & Interact Biol, 15 Ave Flahault, F-34060 Montpellier 2, France Fac Pharm Montpellier 15 Ave Flahault Montpellier France 2 nce
Citazione:
D. Durand et al., "Leukotriene B-4 photoaffinity probes: Design, synthesis and evaluation of new arylazide-1,3-disubstituted cyclohexanes", BIOORG MED, 10(8), 2000, pp. 811-814

Abstract

The synthesis and the binding affinities of new leukotriene Bq receptor photoaffinity probes, where a 1,3-disubstitued cyclohexane ring replaces the conjugated Delta(6.7) and Delta(8.9) double bonds of the natural eicosanoid, are described. One enantiomeric componnd, 4b alpha, is specifically cross-linked upon photolysis to the recombinant leukotriene Bq receptor from human origin (h-BLTR) solubilized in a micellar medium. This probe appears as a good candidate for identifying the ligand binding site of this receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:43:46