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Titolo:
Cognitive impairment and the brain dopaminergic system in Parkinson disease - [F-18]fluorodopa positron emission tomographic study
Autore:
Rinne, JO; Portin, R; Ruottinen, H; Nurmi, E; Bergman, J; Haaparanta, M; Solin, O;
Indirizzi:
Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Abo Akad Univ, Radiopharmaceut Chem & Accelerator Lab, Turku PET Ctr, Turku, Finland Abo Akad Univ Turku Finland elerator Lab, Turku PET Ctr, Turku, Finland
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 4, volume: 57, anno: 2000,
pagine: 470 - 475
SICI:
0003-9942(200004)57:4<470:CIATBD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE DYSFUNCTION; PROGRESSIVE SUPRANUCLEAR PALSY; BASAL GANGLIA; MULTIPLE-SCLEROSIS; CORTEX; MOTOR; PET; PERFORMANCE; DISABILITY; ALZHEIMERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Rinne, JO Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 l, FIN-20520 Turku, Finland
Citazione:
J.O. Rinne et al., "Cognitive impairment and the brain dopaminergic system in Parkinson disease - [F-18]fluorodopa positron emission tomographic study", ARCH NEUROL, 57(4), 2000, pp. 470-475

Abstract

Objective: To investigate the role of the brain dopaminergic system in cognitive impairment in patients with Parkinson disease (PD). Design: We studied 28 patients with PD and 16 age-matched healthy control subjects using [F-18]fluorodopa (fluorodopa F 18) positron emission tomography. Patients with PD showed a variable degree of cognitive impairment, which was assessed using the Mini-Mental State Examination and detailed neuropsychologic assessment, including tests sensitive for frontal lobe function. Results: [F-18]Fluorodopa uptake was reduced in the putamen ito 36% of thecontrol mean: P < .001), the caudate nucleus (to 61% of the control mean: P < .001), and the frontal cortex (to 45% of the control mean: P < .001) inpatients with PD compared with controls. There was no significant association between the degree of overall cognitive impairment of patients and [F-18] fluorodopa uptake values. The influx constant (K-l(occ)) in the caudate nucleus had a negative association with performance in the attention-demanding Stroop interference task, especially with the interference time. The K-l(occ) in the frontal cortex had a positive correlation with performance inthe digit span (backwards) verbal fluency, and verbal immediate recall tests. Thus, the better the patient performed in tasks demanding immediate andworking memory and executive strategies, the better the [F-18]fluorodopa uptake in the frontalcortfs. In the putamen, no significant correlation was seen between the k(l)(occ) value and any of the cognitive tests. The severity of the motor symptoms of PD and [F-18]fluorodopa uptake show ed a negative correlation in the putamen (r = -0.38; P = .04), and in the caudate nucleus a similar trend was seen (r = -0.36; P = .06),Conclusions: Reduced [F-18]fluorodopa uptake in PD in the caudate nucleus (and frontal cortex) is related to impairment in neuropsychologic tests measuring verbal fluency, working memory, and attentional functioning reflecting frontal lobe function. This indicates that dysfunction of the dopamine system has an impact on the cognitive impairment of patients with PD. However, our results do not exclude the possibility of more generalized cognitiveimpairment in PD, the pathophysiology of which is probably different and more generalized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:57:58