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Titolo:
Effect on acute rejection reaction and survival of the heart with the addition of dextran 60 to conventional immunosuppressive therapy in an experimental model of heterotopic heart transplantation
Autore:
Careaga-Reyna, G; Arguero, RS;
Indirizzi:
Hosp Cardiol, Ctr Med Nacl Siglo 21, Div Cirugia Cardiotoracica, IMSS, Mexico City 06725, DF, Mexico Hosp Cardiol Mexico City DF Mexico 06725 S, Mexico City 06725, DF, Mexico
Titolo Testata:
ARCHIVES OF MEDICAL RESEARCH
fascicolo: 1, volume: 31, anno: 2000,
pagine: 37 - 41
SICI:
0188-4409(200001/02)31:1<37:EOARRA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR REJECTION; CELL-ADHESION; REPERFUSION INJURY; CARDIAC ALLOGRAFTS; SALINE-DEXTRAN; DISEASE; CYCLOSPORINE; CRYSTALLOIDS; ENDOTHELIUM; COLLOIDS;
Keywords:
rejection; heart; transplantation; dextran; immunosuppressive therapy; heterotopic transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Careaga-Reyna, G Hosp Cardiol, Ctr Med Nacl Siglo 21, Div Cirugia Cardiotoracica, IMSS, Av Cuauhtemoc 330,Col Doctores, Mexico City 06725, DF, MexicoHosp Cardiol Av Cuauhtemoc 330,Col Doctores Mexico City DF Mexico 06725
Citazione:
G. Careaga-Reyna e R.S. Arguero, "Effect on acute rejection reaction and survival of the heart with the addition of dextran 60 to conventional immunosuppressive therapy in an experimental model of heterotopic heart transplantation", ARCH MED R, 31(1), 2000, pp. 37-41

Abstract

Background. Rejection reaction is an important complication in heart transplantation. Recent physiopathological findings suggest new immunosuppressive alternatives such as the use of substances that block interaction betweenleukocytes and endothelium or subsequent events, The objective of this work was to evaluate the effect of the combination of dextran 60 and conventional immunosuppressive therapy. Methods. We used Sprague-Dawley rats, both sexes, with mean weight of 317.3 +/- 31.3 g on which we carried out heterotopic heart transplantation and then randomized into four groups. All groups received cyclosporine (2 mg/kg/day) and prednisone (0.5 mg/day). Group I (n= 5) also received 0.5 cc/kg/day of dextran 60, group II (n = 5) 1.0 cc/kg/day of dextran 60, group III (n = 5) 2 cc/kg/day, and group IV (n = 4) 0.9% saline solution 0.5 cc/kg/day. The incidence and severity of rejection reaction was evaluated as survival of transplanted hearts. Results. Significant differences were found between groups III and IV for incidence of rejection reaction (p = 0.039). However, there were no differences among groups (grade 3A or 3B) in the magnitude of the rejection reaction. Survival of hearts was better in all groups receiving dextran 60 (p = 0.031). Conclusion. It was concluded that dextran 60 improves survival of transplanted hearts: and decreases incidence of rejection reaction. (C) 2000 IMSS, Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:27:31