Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Eosinophil apoptosis in induced sputum from patients with seasonal allergic rhinitis and with asymptomatic and symptomatic asthma
Autore:
Foresi, A; Teodoro, C; Leone, C; Pelucchi, A; DIppolito, R; Chetta, A; Olivieri, D;
Indirizzi:
Serv Fisiopatol Resp Modulo Allergol & Immunopato, I-20099 Sesto Giovanni,Italy Serv Fisiopatol Resp Modulo Allergol & Immunopato Sesto Giovanni Italy I-20099 Univ Parma, Ist Clin Malattie Apparato Resp, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 attie Apparato Resp, I-43100 Parma, Italy
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 4, volume: 84, anno: 2000,
pagine: 411 - 416
SICI:
1081-1206(200004)84:4<411:EAIISF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHACHOLINE RESPONSIVENESS; BRONCHIAL RESPONSIVENESS; BRONCHOALVEOLAR LAVAGE; MOLECULAR MECHANISMS; ATOPIC ASTHMA; CELL-DEATH; INFLAMMATION; CYTOKINES; AIRWAYS; RESOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Foresi, A Serv Fisiopatol Resp Modulo Allergol & Immunopato, Viale Matteotti 83, I-20099 Sesto Giovanni, Italy Serv Fisiopatol Resp Modulo Allergol &Immunopato Viale Matteotti 83 Sesto Giovanni Italy I-20099
Citazione:
A. Foresi et al., "Eosinophil apoptosis in induced sputum from patients with seasonal allergic rhinitis and with asymptomatic and symptomatic asthma", ANN ALLER A, 84(4), 2000, pp. 411-416

Abstract

Background: Eosinophilic inflammation is known to play an important role in the pathogenesis of allergic diseases, Apoptosis, a form of programmed cell death, is characterized by morphologic cell changes and leads to recognition and ingestion by macrophages. Apoptosis could be an important mechanism controlling the resolution of tissue eosinophilia. Objective: This study was designed to investigate the presence of apoptotic eosinophils in induced sputum of patients with seasonal allergic rhinitis(SAR), when examined during natural pollen exposure and of patients with perennial asthma of different degrees of severity. Methods: We recruited 11 patients with SAR to grass pollens, 26 patients with asymptomatic asthma (AA), and 18 patients with symptomatic asthma (SA). The severity of asthma was assessed by clinical scoring, Sputum was induced following a standard method and differential cell count was estimated. Eosinophils showing cell shrinkage and nuclear coalescence were classified asapoptotic. The number of apoptotic eosinophils was expressed as the percentage of total cells in sputum and as the proportion of apoptotic eosinophils relative to normal bilobed eosinophils ("apoptotic ratio"). Results: We found the number of eosinophils in the SA group was significantly greater than that in the SAR and the AA groups (P < .001 and P < .0001 respectively). The number of apoptotic eosinophils in the AA group was significantly lower than that in the SAR group (P < .001) and in the SA group (P < .0001), The apoptotic ratio for eosinophils in the SAR group was significantly greater than in the AA group (P < .05) and in the SA group (P < .05). There was no difference in the apoptotic ratio between the AA and SA groups. Conclusions: This study confirms that apoptotic eosinophils are detectablein induced sputum of allergic patients. Further, the results of our study suggest that apoptosis could be an important mechanism in the control of acute eosinophilic inflammation in patients with SAR exposed to the sensitizing antigens, It appears that the apoptotic mechanism could be less effective in controlling tissue eosinophilia in asthmatic patients with chronic eosinophilic inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:52:52