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Titolo:
Does prenatal exposure to diethylstilbestrol (DES) have psychiatric consequences?
Autore:
Verdoux, H;
Indirizzi:
Univ Bordeaux 2, Ctr Hosp Charles Perrens, Serv Univ Psychiat, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 ychiat, F-33076 Bordeaux, France
Titolo Testata:
ANNALES MEDICO-PSYCHOLOGIQUES
fascicolo: 2, volume: 158, anno: 2000,
pagine: 105 - 117
SICI:
0003-4487(200002)158:2<105:DPETD(>2.0.ZU;2-2
Fonte:
ISI
Lingua:
FRE
Soggetto:
CEREBRAL LATERALIZATION; OBSTETRIC COMPLICATIONS; STILBESTROL THERAPY; SEX-DIFFERENCES; SCHIZOPHRENIA; WOMEN; PSYCHOPATHOLOGY; METAANALYSIS; EXPERIENCE; HANDEDNESS;
Keywords:
Diethylstilbestrol; DES; neurodevelopment; lateralisation; depression; eating disorder; psychotic disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Verdoux, H Ctr Carreire, 121 Rue Bechade, F-33076 Bordeaux, France Ctr Carreire 121 Rue Bechade Bordeaux France F-33076 x, France
Citazione:
H. Verdoux, "Does prenatal exposure to diethylstilbestrol (DES) have psychiatric consequences?", ANN MED PSY, 158(2), 2000, pp. 105-117

Abstract

Diethylstilbestrol (DES) has been widely used around the word in pregnancycare until the discovery in the early 1970s of the teratogenic and carcinogenic effects of this drug. The genital and obstetrical iatrogenic effects of the intrauterine exposure to DES are now well established However, the potential impact of the DES and related xenoestrogen on the foetal neurodevelopment are poorly known. It has been suggested that prenatal DES exposure may modify the cerebral lateralisation. A more speculative is due wit regard to the possible neurodevelopmental consequences of DES exposure is the possible impact on gender-identity and gender-related behavior. Prenatal DES exposure maya be also a risk factor for psychiatric disorder in adulthood. This increased liability can not be totally explained by the genital and reproductive consequences of DES exposure, since it can also be found before the appearance of such complications and/or in subjects unaware of their exposure to DES, and also exists sin DES-exposed sons who do not present withsomatic complications. Most previous studies have assessed the links between perinatal DES exposure and increased risk of depression. A few reports also suggest that subjects exposed to DES may abe at greater risk of eating or psychotic disorders. Further research on the neuro-developmental consequences for xenoestrogen exposure is required from an aetiological perspective but also from a preventive point of view.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:24:13