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Titolo:
Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent
Autore:
Mishima, K; Matsuyama, K; Tanabe, D; Yamauchi, S; Young, TJ; Johnston, KP;
Indirizzi:
Fukuoka Univ, Dept Chem Engn, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka Japan 8140180 ept Chem Engn, Fukuoka 8140180, Japan Univ Texas, Dept Chem Engn, Austin, TX 78712 USA Univ Texas Austin TX USA78712 exas, Dept Chem Engn, Austin, TX 78712 USA
Titolo Testata:
AICHE JOURNAL
fascicolo: 4, volume: 46, anno: 2000,
pagine: 857 - 865
SICI:
0001-1541(200004)46:4<857:MOPBRE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBON-DIOXIDE; LIQUID-EQUILIBRIA; PRECIPITATION; PARTICLES; SYSTEMS; MICROEMULSIONS; ANTISOLVENT; GENERATION; MORPHOLOGY; SOLUBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Mishima, K Fukuoka Univ, Dept Chem Engn, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka Japan 8140180 gn, Fukuoka 8140180, Japan
Citazione:
K. Mishima et al., "Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent", AICHE J, 46(4), 2000, pp. 857-865

Abstract

A new method-rapid expansion from supercritical solution with a nonsolvent(RESS-N) - is reported for forming polymer microparticles containing proteins such as lysozyme (from chicken egg white) and lipase (from Pseudomonas cepacia). A suspension of protein in CO2 containing a cosolvent and dissolved polymer is sprayed through a nozzle to atmospheric pressure. The polymers are poly(ethylene glycol) (PEG4000; MW = 3,000 PEG6000; MW = 7,500, PEG20000; MW = 20,000) poly(methyl methacrylate) (PMMA; MW = 15,000), poly(L-lactic acid) (PLA; MW = 5,000), poly(DL-lactide-co-glycolide) (PGLA; MW = 5, 000) and PEG - poly(propylene glycol) (PPG) - PEC triblock copolymer (MW = 13,000). The solubilities of these polymers in CO2 increase significantly with low-molecular-weight alcohols as cosolvents. The particles do not tend to agglomerate after expansion, since the pure cosolvent is a nonsolvent forthe polymer. The structure and morphology of the microcapsules were investigated by TEM, SEM, and optical microscopy. The thickness of the polymer coating about the protein, as well as the mean particle diameter and particle-size distribution could be controlled by changing the feed composition of the polymer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:28:18