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Titolo:
Neuronal damage of the substantia nigra in HIV-1 infected brains
Autore:
Itoh, K; Mehraein, P; Weis, S;
Indirizzi:
Otto Von Guericke Univ, Inst Neuropathol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Univ Munich, Inst Neuropathol, Munich, Germany Univ Munich Munich Germany iv Munich, Inst Neuropathol, Munich, Germany
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 4, volume: 99, anno: 2000,
pagine: 376 - 384
SICI:
0001-6322(200004)99:4<376:NDOTSN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS DEMENTIA COMPLEX; HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-DEFICIENCY-SYNDROME; CYTOCHROME-C-OXIDASE; PARKINSONS-DISEASE; EXTRAPYRAMIDAL SYMPTOMS; CEREBRAL TOXOPLASMOSIS; OXIDATION CHEMISTRY; POTENTIAL RELEVANCE; REACTION PATHWAYS;
Keywords:
substantia nigra; extrapyramidal motor disorders; neuronal loss; HIV-1 infection; morphometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Weis, S Otto Von Guericke Univ, Inst Neuropathol, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
K. Itoh et al., "Neuronal damage of the substantia nigra in HIV-1 infected brains", ACT NEUROP, 99(4), 2000, pp. 376-384

Abstract

Extrapyramidal motor disorders are frequently noted in HIV-1-infected patients. In the present study, the substantia nigra was analyzed morphometrically to detect neuronal changes which might contribute to the pathogenetic mechanisms causing extrapyramidal motor dysfunction in HIV-1-infected patients. The numerical density and the size of pigmented, non-pigmented small, and non-pigmented large neurons in four nuclei of the substantia nigra pars compacta (antero-medial, antero-intermediolateral, postero-lateral, and postero-medial nuclei) in HIV-1-infected patients and in age-matched normal controls were determined. In HIV-1-infected brains, the numerical density of total neurons (i.e.. pigmented and non-pigmented) as well as of pigmented neurons was significantly decreased, whereas that of non-pigmented neurons was not significantly changed in all investigated nuclei of the substrantia nigra as compared to normal controls. A specific pattern of increase and decrease of nonpigmented large and non-pigmented small neurons was observed. The size of total neurons (pigmented and nonpigmented neurons) and of pigmented neurons was significantly reduced in all investigated nuclei of HIV-1-infected brains. The results suggest that neuronal degeneration in the substantia nigra commonly occurs and may be related to extrapyramidal symptoms in HIV-1-infected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:50:43