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Titolo:
Improved endocardial border delineation during dobutamine stress echocardiography using the left heart contrast agent BY 963
Autore:
Frieske, R; Kuhl, H; Yuan, D; Lepper, W; Franke, A; Hoffmann, R;
Indirizzi:
RWTH Aachen Klinikum, Med Klin 1, D-52072 Aachen, Germany RWTH Aachen Klinikum Aachen Germany D-52072 n 1, D-52072 Aachen, Germany
Titolo Testata:
ZEITSCHRIFT FUR KARDIOLOGIE
fascicolo: 3, volume: 89, anno: 2000,
pagine: 186 - 194
SICI:
0300-5860(200003)89:3<186:IEBDDD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
GER
Soggetto:
III MULTICENTER TRIAL; ALBUMIN; ALBUNEX; OPACIFICATION; DEFINITION;
Keywords:
dobutamine stress echocardiography; contrast agent; endocardial detection; BY 963;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hoffmann, R RWTH Aachen Klinikum, Med Klin 1, Pauwelsstr, D-52072 Aachen, Germany RWTH Aachen Klinikum Pauwelsstr Aachen Germany D-52072 ermany
Citazione:
R. Frieske et al., "Improved endocardial border delineation during dobutamine stress echocardiography using the left heart contrast agent BY 963", Z KARDIOL, 89(3), 2000, pp. 186-194

Abstract

The interpretation of induced wall motion abnormalities during dobutamine stress echocardiography is affected in the case of impaired image quality. In 48 consecutive patients (mean age 62+/-9 years, 32 males, 16 females) with suspected coronary disease undergoing coronary angiography, the transpulmonary contrast agent BY 963 was given i.v. as bolus during dobutamine stress echocardiography (10-40 mu g kg min, plus max. 1 mg atropine) to analyze improvements in endocardial border delineation. For each of the 16 segments of the left ventricle, the endocardial border delineation was evaluated. Using BY 963 the average number of non-evaluable segments decreased by 58%from 5.2% to 2.2% at rest (p=0.008) and by 56% from 5.9% to 2.6% at maximal stress (p=0.003) as compared to the noncontrast study for all patients. In patients with impaired image quality, defined as at least 1 non-evaluablesegment at rest without contrast enhancement (N = 14), the number of non-evaluable segments decreased from 19.2% to 8.2% (p=0.004) at rest and from 19.2% to 9.6% (p=0.006) at maximal stress. The greatest decrease of non-evaluable segments was seen in the lateral and anterior segments of the apical views (maximum of 80%). The improved endocardial border delineation resulted in an improved agreement between two observers in the interpretation of the dobutamine stress echocardiograms as positive or negative (kappa=0.38 without contrast, kappa=0.58 with contrast). Contrast application resulted ina slight improvement of diagnostic accuracy of dobutamine stress echocardiography in the detection of angiographically proven significant coronary artery disease. Conclusion: In patients with impaired endocardial border delineation the use of the echo contrast agent BY 963 reduces the number of non-evaluable segments. Improvement of endocardial delineation is greatest for lateral and anterior segments in the apical views.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:30:14