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Titolo:
Immunoadjuvant activities of E-coli- and plasmid-expressed recombinant chicken IFN-alpha/beta, IFN-gamma and IL-1 beta in 1-day- and 3-week-old chickens
Autore:
Schijns, VECJ; Weining, KC; Nuijten, P; Rijke, EO; Staeheli, P;
Indirizzi:
Intervet Int BV, Dept Vaccine Technol & Immunol, NL-5830 AA Boxmeer, Netherlands Intervet Int BV Boxmeer Netherlands NL-5830 AA 0 AA Boxmeer, Netherlands Univ Freiberg, Dept Virol, Freiburg, Germany Univ Freiberg Freiburg Germany Freiberg, Dept Virol, Freiburg, Germany Intervet Int BV, Dept Bacteriol, NL-5830 AA Boxmeer, Netherlands Intervet Int BV Boxmeer Netherlands NL-5830 AA 0 AA Boxmeer, Netherlands Intervet Int BV, Dept Aquaculture, NL-5830 AA Boxmeer, Netherlands Intervet Int BV Boxmeer Netherlands NL-5830 AA 0 AA Boxmeer, Netherlands
Titolo Testata:
VACCINE
fascicolo: 20, volume: 18, anno: 2000,
pagine: 2147 - 2154
SICI:
0264-410X(20000414)18:20<2147:IAOEAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; IMMUNE-RESPONSES; T-CELLS; IN-VIVO; DENDRITIC CELLS; TRANSGENIC MICE; EARLY-LIFE; CYTOKINES; VACCINE; ADJUVANTS;
Keywords:
chicken; cytokine; vaccine; adjuvant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Schijns, VECJ Intervet Int BV, Dept Vaccine Technol & Immunol, POB 31, NL-5830 AA Boxmeer, Netherlands Intervet Int BV POB 31 Boxmeer Netherlands NL-5830 AA lands
Citazione:
V.E.C.J. Schijns et al., "Immunoadjuvant activities of E-coli- and plasmid-expressed recombinant chicken IFN-alpha/beta, IFN-gamma and IL-1 beta in 1-day- and 3-week-old chickens", VACCINE, 18(20), 2000, pp. 2147-2154

Abstract

In the present study we assessed the capacity of recombinant E. coli- or plasmid-expressed chicken interferons (IFN) and chicken IL-I beta, to exert immunostimulatory activities for humoral immune responses, in day-old and adult chickens. We observed that both recombinant E. coli-expressed chicken IFN-alpha/beta and IFN-gamma facilitated the induction of a primary and also a secondary antibody response, using tetanus toroid (TT) as a bacterial model antigen, in immunologically mature 3-week-old chickens. In contrast, no improvement of antibody responses were noted when either type of chicken IFN was co-injected with inactivated Infectious Bursal Disease Virus (IBDV)antigen. TT-specific antibody formation was marginally increased by coinjection of recombinant E. coli-expressed chicken IL-1 beta. Combined administration of IFN-alpha/beta plus IFN-gamma or IL-beta increased responses to TT in an additive, but not synergistic fashion. Remarkably, no augmentation of antibody responses specific for TT, nor IBDV, was noted in day-old birds, receiving IFN-alpha/beta or IFN-gamma as adjuvant. Also, intramuscular immunization of 3-week-old birds, using plasmids encoding IFN-alpha/beta together with TT protein antigen, significantly increased the speed and magnitude of TT-specific antibody responses. Plasmids encoding chicken IL-beta or IFN-gamma had a minimal or inhibitory effect, respectively. These data indicate a potential for chicken cytokines as immunoadjuvant for particular types of chicken vaccine antigens. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:58:21