Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evaluation of the extension of cerebral gliomas by scintigraphy
Autore:
Weckesser, M; Matheja, P; Rickert, C; Lottgen, J; Palkovic, S; Riemann, B; Paulus, W; Wassmann, H; Schober, O;
Indirizzi:
Univ Munster, Dept Nucl Med, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 Nucl Med, D-48149 Munster, Germany Univ Munster, Inst Neuropathol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 uropathol, D-48149 Munster, Germany Univ Munster, Dept Neurosurg, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 Neurosurg, D-48149 Munster, Germany
Titolo Testata:
STRAHLENTHERAPIE UND ONKOLOGIE
fascicolo: 4, volume: 176, anno: 2000,
pagine: 180 - 185
SICI:
0179-7158(200004)176:4<180:EOTEOC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE PET; ALPHA-METHYL TYROSINE; BRAIN-TUMORS; IODINE-123-ALPHA-METHYL TYROSINE; L-3-IODO-ALPHA-METHYL TYROSINE; METHIONINE UPTAKE; MALIGNANT GLIOMA; TL-201; SPECT;
Keywords:
glioma; scintigraphy; amino acid; SPECT; blood brain barrier;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Weckesser, M Univ Munster, Dept Nucl Med, Albert Schweitzer Str 33, D-48149 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48149
Citazione:
M. Weckesser et al., "Evaluation of the extension of cerebral gliomas by scintigraphy", STRAH ONKOL, 176(4), 2000, pp. 180-185

Abstract

Background: Single photon emission computed tomography (SPECT) with Tl-201and I-123-alpha-methyl tyrosine (I-123-IMT) are routine methods for the evaluation of brain tumors. I-123-IMT transport across the blood brain barrier is mediated by an amino acid carrier, Tl-201 accumulation is analogous tocerebral potassium uptake. Patients and Methods: To determine the differences in glioma extension as shown by the 2 methods, 17 patients with malignant gliomas were included inthis comparative imaging study: astrocytoma III: n = 6, ependymoma III: n = 1, oligodendroglioma III: n = 1, glioblastoma IV: n = 9. The tomographic image sets were matched anatomically and the slices showing maximal tumor extension were identified in both image sets respectively. Tumor spread was compared visually and the tumor extension was quantified. Results: In gliomas WHO III tumor extension was delineated significantly larger by I-123-IMT-SPECT than by Tl-201-SPECT (mean +/- SD: 816 +/- 281 pixels vs 600 +/- 220 pixels, n = 8, p < 0.05). The size of glioblastomas was shown in a comparable manner by the 2 methods (977 +/- 571 vs 1.051 +/- 588, n = 9, ns, p = 0.57, but there were considerable regional differences between the area of Tl-201 uptake and amino acid retention, in the whole groupa weak but significant negative correlation between intensity of Tl-201 uptake on the one hand and a ratio of the area as depicted by I-123-IMT vs area as depicted by Tl-201 on the other hand, was found (n = 17, r = 0.49, p < 0.05), Thus the differences in the delineation of areas became smaller with increasing Tl-201 uptake. Conclusions: These preliminary data indicate that the extension of gliomasis depicted differently by the 2 methods. IMT-SPECT shows a larger tumor extension especially in gliomas WHO III. Since Tl-201 uptake has previously been shown to correlate with disruption of the blood brain barrier, I-123-IMT-SPECT may delineate tumor parts without endothelial leakage. This additional information may be helpful in planning surgical or radiation therapy. The advantages of I-123-IMT in this respect decrease with increasing Tl-201uptake and with increasing malignancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 19:44:18