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Titolo:
Hematopoietic stem cell transplantation for systemic lupus erythematosus
Autore:
Brodsky, RA; Petri, M; Jones, RJ;
Indirizzi:
Johns Hopkins Univ, Sch Med, Hopkins Lupus Cohort, Baltimore, MD USA JohnsHopkins Univ Baltimore MD USA kins Lupus Cohort, Baltimore, MD USA Johns Hopkins Oncol Ctr, Div Immunol & Hematopoiesis, Baltimore, MD USA Johns Hopkins Oncol Ctr Baltimore MD USA ematopoiesis, Baltimore, MD USA
Titolo Testata:
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
fascicolo: 2, volume: 26, anno: 2000,
pagine: 377 -
SICI:
0889-857X(200005)26:2<377:HSCTFS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; HIGH-DOSE CYCLOPHOSPHAMIDE; PERIPHERAL-BLOOD STEM; SEVERE APLASTIC-ANEMIA; CHRONIC MYELOGENOUS LEUKEMIA; AUTOIMMUNE-DISEASES; ALDEHYDE DEHYDROGENASE; MULTIPLE-SCLEROSIS; MYASTHENIA-GRAVIS; THALASSEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Brodsky, RA Bunting Blaustein Canc Res Bldg,Room 2L42,1650 Or, Baltimore, MD 21231 USA Bunting Blaustein Canc Res Bldg,Room 2L42,1650 Or Baltimore MD USA 21231
Citazione:
R.A. Brodsky et al., "Hematopoietic stem cell transplantation for systemic lupus erythematosus", RHEUM DIS C, 26(2), 2000, pp. 377

Abstract

Many institutions worldwide are conducting clinical studies using immunoablative therapy followed by hematopoietic stem cell transplantation for the treatment of SLE. Interpretation of these studies will be complicated by the differences in patient selection, conditioning regimens, and the method of stem cell collection. A major concern with this approach is that autoreactive effector cells will be re-infused with the autologous graft. The recent demonstration that immunoablative therapy (cyclophosphamide 200 mg/kg) can be safely delivered without the need for stem cell rescue offers a potential way to circumvent this problem. Early results employing immunoablative therapy, with or without stem cell rescue, are encouraging; however, longerfollow-up and additional patients are necessary to validate this approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:11:29