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Titolo:
Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats
Autore:
Yildiz, F; Erden, BF; Ulak, G; Utkan, T; Gacar, N;
Indirizzi:
Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 Pharmacol, TR-41900 Kocaeli, Turkey
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 149, anno: 2000,
pagine: 41 - 44
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; APPARENT ANXIOLYTIC PROPERTIES; POTENT ANTICONVULSANT; 10-IMINE MK-801; 7-NITRO INDAZOLE; NERVOUS-SYSTEM; NMDA RECEPTORS; SUBSTANCE; MODEL; 11-DIHYDRO-5H-DIBENZOCYCLOHEPTEN-5;
Keywords:
nitric oxide; 7-nitroindazole; forced swimming test; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Yildiz, F Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 TR-41900 Kocaeli, Turkey
Citazione:
F. Yildiz et al., "Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats", PSYCHOPHAR, 149(1), 2000, pp. 41-44

Abstract

Rationale: There is some strong evidence about the role of nitric oxide (NO) as an intercellular messenger in central physiological mechanisms. NO issynthesized from L-arginine by nitric oxide synthase (NOS), as a response to activation of N-methyl-D-aspartate (NMDA) receptors by excitatory amino acids. NMDA receptor antagonists also produce antidepressant-like actions in preclinical models. Objective: In the present study, the involvement of NO in the mechanism of depression was investigated. 7-Nitroindazole (7-NI) (15, 30, 60, 90 mg/kg IF), a selective inhibitor of neuronal NOS was examined. Methods: The Porsolt forced swimming test (FST) has been used as a test for screening new antidepressant agents. Results: 7-NI dose-dependently decreased the immobility time in FST, but produced no significant change in locomotor activity in naive rats. Neither L-arginine, nor D-arginine (100 mg/kg) affected the immobility time in the FST or revealed any effect on locomotion. L-Arginine but not D-arginine, given 10 min before 7-NI, reversed the 7-NI-induced effect on immobility time. Conclusion: Our findings suggest that NO might be an important modulator of depression in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:48:34