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Titolo:
Effects of subchronic paroxetine administration on night-time endocrinological profiles in healthy male volunteers
Autore:
Schlosser, R; Wetzel, H; Dorr, H; Rossbach, W; Hiemke, C; Benkert, O;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 4, volume: 25, anno: 2000,
pagine: 377 - 388
SICI:
0306-4530(200005)25:4<377:EOSPAO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT TREATMENTS; HORMONE-SECRETION; DEPRESSION; RATS; AMITRIPTYLINE; PHARMACOLOGY; MECHANISMS; INHIBITOR; SYSTEM;
Keywords:
neuroendocrinology; antidepressants; selective serotonin reuptake inhibitor; sleep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schlosser, R Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55131 any
Citazione:
R. Schlosser et al., "Effects of subchronic paroxetine administration on night-time endocrinological profiles in healthy male volunteers", PSYCHONEURO, 25(4), 2000, pp. 377-388

Abstract

To evaluate the subchronic effects of paroxetine, a selective serotonin reuptake inhibitor, on nocturnal endocrinological profiles, eight healthy male volunteers with no personal or family history of a psychiatric or neurological disease were administered paroxetine (30 mg/day) or placebo in a double-blind cross-over design. Drugs were given as a single dose at 10:00 h for a period of 4 weeks each. Between days 21 and 28 of each treatment period, sleep EEG was registered for four consecutive nights from 23:00 to 07:00 h. During the last night, hormonal profiles for prolactin, growth hormone (GH), cortisol, corticotropin (ACTH), luteinizing hormone (LH), testosteroneand melatonin were determined, and area-under-the-curve values were calculated. None of the endocrinological parameters revealed any statistically significant changes. A trend could be found for an increased cortisol production under paroxetine (P = 0.069). ACTH, LH, and melatonin showed slight andnon-significant decreases. Prolactin release was only marginally elevated ( + 7%). The mean sleep onset GH release (as measured for a time period of 180 min after sleep onset) was decreased by about 30% under paroxetine. However. statistical significance could not be reached. For hGH, there was a delayed mean GH-peak under paroxetine. Nocturnal testosterone secretion remained almost unaltered. The lack of significant endocrinological alterationsmight be partially explained by both adaptational phenomena under subchronic treatment conditions and the extended time span between the single morning dose and the registration period, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:43:16