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Titolo:
Preliminary findings of simultaneous F-18-FDG and Tc-99m-HMPAO SPECT in patients with depressive disorders at rest: differential correlates with ratings of anxiety
Autore:
Conca, A; Fritzsche, H; Peschina, W; Konig, P; Swoboda, E; Wiederin, H; Haas, C;
Indirizzi:
LKH Rankweil, Dept Psychiat 1, Rankweil, Austria LKH Rankweil Rankweil Austria kweil, Dept Psychiat 1, Rankweil, Austria LKH Feldkirch, Dept Nucl Med, Feldkirch, Austria LKH Feldkirch FeldkirchAustria irch, Dept Nucl Med, Feldkirch, Austria LKH Feldkirch, Dept Med Phys, Feldkirch, Austria LKH Feldkirch FeldkirchAustria irch, Dept Med Phys, Feldkirch, Austria
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 98, anno: 2000,
pagine: 43 -
SICI:
0925-4927(20000228)98:1<43:PFOSFA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; OBSESSIVE-COMPULSIVE DISORDER; GLUCOSE METABOLIC RATES; UNIPOLAR DEPRESSION; NEURAL ACTIVITY; TOMOGRAPHY; CORTEX; PET;
Keywords:
single photon emission computed tomography; glucose metabolic rate; regional cerebral blood flow; anxiety; affective disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Conca, A LKH Rankweil, Dept Psychiat 1, Vahmastrt, Rankweil, Austria LKH Rankweil Vahmastrt Rankweil Austria strt, Rankweil, Austria
Citazione:
A. Conca et al., "Preliminary findings of simultaneous F-18-FDG and Tc-99m-HMPAO SPECT in patients with depressive disorders at rest: differential correlates with ratings of anxiety", PSYCH RES-N, 98(1), 2000, pp. 43

Abstract

The assumption of a dynamic coupling between regional cerebral blood flow (rCBF) and cerebral glucose metabolic rates (rCMRGlu) has been challenged by simultaneous measurements of both. Through the use of a dual-headed gammacamera with a 511-keV collimator applying the double isotope F-18-FDG and Tc-99m-HMPAO SPECT technique, the uptake rates of these isotopes can be semi-quantitatively evaluated. Sixteen depressed patients, diagnosed by ICD-10criteria and assessed with the 17-item Hamilton Rating Scale for Depression (HRSD), were studied. Based on the severity of HRSD-rated anxiety (item 10: low = 1-21; high = 3-4), two eight-patient subgroups were formed and compared with 12 age- and handedness-matched healthy control subjects. As regions of interest, we selected areas implicated in the neuroanatomy of anxiety and depression: hippocampus (hippo), basal ganglia (BG) and gyri temporales superiores (G.t.s.). In the control subjects, a significant statistical coupling between rCBF and rCMRGlu was revealed by the Spearman correlation coefficient only in left hippo and left BG. Patients in the low-anxiety subgroup demonstrated a marked dynamic coupling bilaterally for the G.t.s., while patients in the high-anxiety subgroup showed a significant statistical correlation of rCBF and rCMRGlu only in the left G.t.s. These findings indicate that a dynamic coupling between blood flow and glucose metabolism exists only in distinct brain regions, and that the depressive illness has an uncoupling effect on this correlation in the left BG. Furthermore, our results suggest that the HRSD anxiety score might interact with the underlying depressive illness to influence the relationship of rCBF and rCMRGlu. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 18/01/20 alle ore 07:29:51