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Titolo:
Fetal tissue transplants in animal models of Huntington's disease: the effects on damaged neuronal circuitry and behavioral deficits
Autore:
Nakao, N; Itakura, T;
Indirizzi:
Wakayama Med Coll, Dept Neurol Surg, Wakayama 640, Japan Wakayama Med Coll Wakayama Japan 640 pt Neurol Surg, Wakayama 640, Japan
Titolo Testata:
PROGRESS IN NEUROBIOLOGY
fascicolo: 3, volume: 61, anno: 2000,
pagine: 313 - 338
SICI:
0301-0082(200006)61:3<313:FTTIAM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRASTRIATAL STRIATAL TRANSPLANTS; CEREBRAL GLUCOSE-UTILIZATION; ACID-LESIONED STRIATUM; ADULT-RAT BRAIN; LATERAL GANGLIONIC EMINENCE; SKILLED FORELIMB USE; UNILATERAL NEOSTRIATAL LESIONS; HOST DOPAMINERGIC AFFERENTS; CENTRAL-NERVOUS-SYSTEM; DRUG-INDUCED ROTATION;
Keywords:
DARPP-32; striatum; neural transplantation; neural circuitry;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
203
Recensione:
Indirizzi per estratti:
Indirizzo: Nakao, N Wakayama Med Coll, Dept Neurol Surg, Wakayama 640, Japan WakayamaMed Coll Wakayama Japan 640 Surg, Wakayama 640, Japan
Citazione:
N. Nakao e T. Itakura, "Fetal tissue transplants in animal models of Huntington's disease: the effects on damaged neuronal circuitry and behavioral deficits", PROG NEUROB, 61(3), 2000, pp. 313-338

Abstract

Accumulating evidence indicates that grafts of embryonic neurons achieve the anatomical and functional reconstruction of damaged neuronal circuitry. The restorative capacity of grafted embryonic neural tissue is most illustrated by studies with striatal tissue transplantation in animals with striatal lesions. Striatal neurons implanted into the lesioned striatum receive some of the major striatal afferents such as the nigrostriatal dopaminergic inputs and the gluatmatergic afferernts from the neocortex and thalamus. The grafted neurons also send efferents to the primary striatal targets, including the globus pallidus (GP, the rodent homologue of the external segmentof the globus pallidus) and the entopeduncular nucleus (EP, the rodent homologue of the internal segment of the globus pallidus). These anatomical connections provide the reversal of the lesion-induced alterations in neuronal activities of primary and secondary striatal targets. Furthermore, intrastriatal striatal grafts improve motor and cognitive deficits seen in animals with striatal lesions. Since the grafts affect motor and cognitive behaviors that are critically dependent on the integrity of neuronal circuits of the basal ganglia, the craft-mediated recovery in these behavioral deficitsis most likely attributable to the functional reconstruction of the damaged neuronal circuits. The fact that the extent of the behavioral recovery ispositively correlated to the amount of grafted neurons surviving in the striatum encourages this view. Based on the animal studies, embryonic striatal tissue grafting could be a viable strategy to alleviate motor and cognitive disorders seen in patients with Huntington's disease where massive degeneration of striatal neurons occurs. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:37:22