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Titolo:
Messenger RNA for membrane-type 2 matrix metalloproteinase, MT2-MMP, is expressed in human placenta of first trimester
Autore:
Bjorn, SF; Hastrup, N; Larsen, JF; Lund, LR; Pyke, C;
Indirizzi:
Rigshosp, Finsen Lab, DK-2100 Copenhagen O, Denmark Rigshosp Copenhagen Denmark O Finsen Lab, DK-2100 Copenhagen O, Denmark Herlev Univ Hosp, Dept Obstet & Gynecol, DK-2730 Herlev, Denmark Herlev Univ Hosp Herlev Denmark DK-2730 Gynecol, DK-2730 Herlev, Denmark Herlev Univ Hosp, Dept Pathol, DK-2730 Herlev, Denmark Herlev Univ Hosp Herlev Denmark DK-2730 Pathol, DK-2730 Herlev, Denmark Novo Nordisk AS, Histol, DK-2880 Bagsvaerd, Denmark Novo Nordisk AS Bagsvaerd Denmark DK-2880 ol, DK-2880 Bagsvaerd, Denmark
Titolo Testata:
PLACENTA
fascicolo: 2-3, volume: 21, anno: 2000,
pagine: 170 - 176
SICI:
0143-4004(200003/04)21:2-3<170:MRFM2M>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGELATINASE-A; CDNA LIBRARY; MICE; INVASION; CELLS; IDENTIFICATION; ACTIVATION; MECHANISM; SURFACE; INSITU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Bjorn, SF Rigshosp, Finsen Lab, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark Rigshosp Strandboulevarden 49 Copenhagen Denmark O n O, Denmark
Citazione:
S.F. Bjorn et al., "Messenger RNA for membrane-type 2 matrix metalloproteinase, MT2-MMP, is expressed in human placenta of first trimester", PLACENTA, 21(2-3), 2000, pp. 170-176

Abstract

An intimately regulated cell surface activation of matrix metalloproteinases (MMPs) is believed to be of critical importance for the control of trophoblast invasion. A histological investigation of the expression and localization of three different MMPs, the membrane-type matrix metalloproteinases 1 and 2 (MT1-MMP, MT2-MMP) and matrix metalloproteinase 2 (MMP-2/gelatinaseA) was performed by in situ hybridization on consecutive sections from human placentae of first trimester pregnancies. Cytokeratin immunostaining identified trophoblast cells. Both normal and tubal implantation sites were studied. We observed a high degree of coexpression of MT2-MMP, MT1-MMP and MMP-2 mRNAs in single extravillous cytotrophoblasts that had invaded the endometrium and tubal wall. Furthermore, mRNAs for all three genes were also seen in cytotrophoblasts of cell islands. In contrast to this coexpression pattern, MT2-MMP expression was absent from cell columns and decidual cells, in which signals for MT1-MMP and MMP-2 mRNAs were seen. The present data onthe cellular expression of MT2-MMP mRNA in placenta extend our knowledge of the proteolytic events that take place during early pregnancy. The data suggest that MT2-MMP, capable of activating MMP-2 in vitro, is involved in the invasion of extravillous cytotrophoblast, possibly related to the physiological activation of MMP-2. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:05:16