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Titolo:
Pre-eclampsia does not change the adhesion molecule status in the placental bed
Autore:
Jaakkola, K; Jokimaa, V; Kallajoki, M; Jalkanen, S; Ekholm, E;
Indirizzi:
Univ Turku, Natl Publ Hlth Inst, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 l Hlth Inst, FIN-20520 Turku, Finland Univ Turku, Medicity Res Lab, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ity Res Lab, FIN-20520 Turku, Finland Univ Turku, Dept Med, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 u, Dept Med, FIN-20520 Turku, Finland Univ Turku, Dept Pathol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Pathol, FIN-20520 Turku, Finland Univ Turku, Dept Obstet & Gynecol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 t & Gynecol, FIN-20520 Turku, Finland
Titolo Testata:
PLACENTA
fascicolo: 2-3, volume: 21, anno: 2000,
pagine: 133 - 141
SICI:
0143-4004(200003/04)21:2-3<133:PDNCTA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMING T-CELLS; MONOCLONAL-ANTIBODY; ENDOTHELIAL DYSFUNCTION; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; LYMPHOCYTE BINDING; TERM PLACENTA; PREECLAMPSIA; EXPRESSION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ekholm, E Turku Univ Hosp, Dept Obstet & Gynecol, FIN-20520 Turku, FinlandTurku Univ Hosp Turku Finland FIN-20520 N-20520 Turku, Finland
Citazione:
K. Jaakkola et al., "Pre-eclampsia does not change the adhesion molecule status in the placental bed", PLACENTA, 21(2-3), 2000, pp. 133-141

Abstract

During normal placentation trophoblast cells invade maternal tissues and remodel the uterine arteries into low-resistance channels. In pre-eclampsia,trophoblast invasion is impaired and this, along with endothelial dysfunction, has been suggested to play a role in the pathogenesis of pre-eclampsia. We studied the expression of adhesion molecules important for leukocyte extravasation in the placental bed with immunohistochemistry and compared the expression in pre-eclampsia to that in normal pregnancy. Our major finding was that only invasive trophoblasts expressed cutaneous lymphocyte antigen-1 (CLA-1) in the third trimester of pregnancy, whereas villous trophoblasts did not. In the first trimester both villous trophoblasts and invasive trophoblast cells in decidua remained negative for CLA-1. Pre-eclampsia did not change the expression of leukocyte-endothelium adhesion or lymphocyte homing-associated antigens, ICAM-1, ICAM-2, VCAM, P-selectin, E-selectin, L-selectin, CLA-1, CD73, VAP-1 and alpha E beta 7 in the placental bed. Furthermore, pre-eclampsia was not associated with an aberrant accumulation of lymphocytes carrying antigens of any particular known organ-specific homing systems. The results on the unchanged pattern of adhesion molecule expression in pre-eclampsia suggests that there is no major change in the adhesive properties of the endothelium of the placental bed in pre-eclampsia. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:30:32