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Titolo:
EFFECTS ON BONE MASS AFTER 8 YEARS OF HORMONAL REPLACEMENT THERAPY
Autore:
EIKEN P; NIELSEN SP; KOLTHOFF N;
Indirizzi:
CENT HOSP HILLEROD,DEPT CLIN PHYSIOL,HELSEVEJ 2 DK-3400 HILLEROD DENMARK
Titolo Testata:
British journal of obstetrics and gynaecology
fascicolo: 6, volume: 104, anno: 1997,
pagine: 702 - 707
SICI:
0306-5456(1997)104:6<702:EOBMA8>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POST-MENOPAUSAL WOMEN; DXA PENCIL-BEAM; ESTROGEN THERAPY; HIP FRACTURE; ELDERLY WOMEN; FAN-BEAM; OSTEOPOROSIS; RISK; WITHDRAWAL; GESTAGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
P. Eiken et al., "EFFECTS ON BONE MASS AFTER 8 YEARS OF HORMONAL REPLACEMENT THERAPY", British journal of obstetrics and gynaecology, 104(6), 1997, pp. 702-707

Abstract

Objective The purpose of this randomised double-blind placebo-controlled study over two years followed by a six year open controlled extension phase was to investigate the effects of hormonal replacement therapy (HRT) both continuous combined HRT and sequential HRT) versus no treatment on lumbar spine bone mineral density (L-BMD) and distal forearm bone mineral content (F-BMC). Further, bone mineral density of the proximal femur, lateral spine, and distal forearm was studied after eight years. Design Prospective study of normal, early postmenopausal women, initially in a double-blind, placebo controlled study, subsequently an open, controlled investigation. Setting Clinical physiology unit of a general second degree referral hospital.Sample Seventy-three normal, early postmenopausal women (HRT n = 47; placebo/untreated n = 26). Methods Dual photon absorptiometry, dual X-ray absorptiometry, singlephoton absorptiometry. Main outcome measures HRT resulted in a significantly (P < 0.001) higher mean L-BMD after eight years, when it was 12.1% higher than the mean initial value and 14.8% higher than the meanbone mineral density of the untreated group. L-BMD increased by 14.6%in women receiving continuous combined HRT compared with 11.1% in those on sequential HRT but intergroup differences were not statisticallysignificant, Mean F-BMC measured with SPA decreased in the HRT group and in the placebo/untreated group by 0.2% and 14.8% (P < 0.001), respectively. However, after eight years mean F-BMC was 14.5% higher in the HRT group than in the placebo/untreated group, The study showed after eight years for all regions of the distal radius and ulna a significantly higher bone mineral density value compared with the placebo/untreated group (P < 0.001). An especially large effect of HRT was found on the bone mineral density of the vertebral body of the 3rd lumbar vertebra (L3), this one, measured by lateral scanning, being 18.7% higherthan that of the placebo/untreated group. For the proximal femur, only the bone mineral density of Ward's triangle was significantly higherin the HRT group than in the placebo/untreated group. Conclusion Eight years of treatment with HRT resulted in a significant, substantial gain of bone mineral density in the lumbar spine. The distal radius, ulna and Ward's triangle showed a significantly higher bone mineral density in the HRT group compared with the placebo/untreated group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:24:25