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Titolo:
Increased levels of expression of an NMDARI splice variant in the superiortemporal gyrus in schizophrenia
Autore:
Le Corre, S; Harper, CG; Lopez, P; Ward, P; Catts, S;
Indirizzi:
Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 Pathol, Sydney, NSW 2006, Australia Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia h Psychiat, Sydney, NSW, Australia
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 11, anno: 2000,
pagine: 983 - 986
SICI:
0959-4965(20000407)11:5<983:ILOEOA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY SENSORY MEMORY; MESSENGER-RNA; MISMATCH NEGATIVITY; RECEPTOR SUBUNITS; SEQUENCE-ANALYSIS; HUMAN HIPPOCAMPUS; GENE-EXPRESSION; BRAIN; GLUTAMATE; CLONING;
Keywords:
gene expression; in situ hybridization histochemistry; NMDARI; schizophrenia; splice variants; superior temporal gyrus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Le Corre, S Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ey, NSW 2006, Australia
Citazione:
S. Le Corre et al., "Increased levels of expression of an NMDARI splice variant in the superiortemporal gyrus in schizophrenia", NEUROREPORT, 11(5), 2000, pp. 983-986

Abstract

Expression patterns of mRNAs for the NMDAR1 subunit (NRI) carboxy-terminusisoforms were investigated in postmortem brain tissue using isotopic in situ hybridization. Three brain regions (superior temporal, middle frontal and visual cortices) were examined in patients with schizophrenia (n = 6) andcontrol subjects (n = 6). A 22% higher level of expression of the NRI isoform that contains neither spliced exon was observed in the superior temporal gyrus of patients with schizophrenia compared with controls (p=0.01). No differences were observed in the expression of the other isoforms in the three regions studied. These data suggest that NRI alternative splicing mightbe abnormal in schizophrenia and reinforce previous findings implicating the superior temporal gyrus as a site of neural dysfunction in schizophrenia. NeuroReport 11:983-986 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:59:15