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Titolo:
The control of blepharospasm by essential fatty acids
Autore:
Mostofsky, DI; Yehuda, S; Rabinovitz, S; Carasso, R;
Indirizzi:
Bar Ilan Univ, Dept Psychol, Psychopharmacol Lab, Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel , Psychopharmacol Lab, Ramat Gan, Israel
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 3, volume: 41, anno: 2000,
pagine: 154 - 157
SICI:
0302-282X(2000)41:3<154:TCOBBE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT FRONTAL-CORTEX; PAIN THRESHOLD; MOTOR-ACTIVITY; DOPAMINE; THERMOREGULATION; MODULATION; METABOLISM; RELEASE;
Keywords:
blepharospasm; fatty acids; linoleic acid; alpha-linolenic acid; dopamine deficiency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Mostofsky, DI Boston Univ, Dept Psychol, Lab Expt Behav Med, 64 CummingtonSt, Boston, MA 02215 USA Boston Univ 64 Cummington St Boston MA USA 02215 A 02215 USA
Citazione:
D.I. Mostofsky et al., "The control of blepharospasm by essential fatty acids", NEUROPSYCHB, 41(3), 2000, pp. 154-157

Abstract

Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from a specific ratio of two free polyunsaturated fatty acids - linoleic acid and a-linolenic acid - the eye blinking rate following administration of Ro4-1284 is reduced to saline and no drug control levels. These results suggest a favorable prospect for essential fatty acids in general, and SR-3 in particular, to provide an improved therapeutic option forthe clinical management of benign essential blepharospasm. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 14:14:15