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Titolo:
Lipopolysaccharides of a Campylobacter coli isolate from a patient with Guillain-Barre syndrome display ganglioside mimicry
Autore:
Bersudsky, M; Rosenberg, P; Rudensky, B; Wirguin, I;
Indirizzi:
Ben Gurion Univ Negev, Soroka Med Ctr, Dept Neurol, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel Ben Gurion Univ Negev, Goldman Fac Hlth Sci, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel Shaare Zedek Med Ctr, Dept Neurol, Jerusalem, Israel Shaare Zedek Med CtrJerusalem Israel r, Dept Neurol, Jerusalem, Israel Shaare Zedek Med Ctr, Dept Clin Microbiol, Jerusalem, Israel Shaare Zedek Med Ctr Jerusalem Israel Clin Microbiol, Jerusalem, Israel
Titolo Testata:
NEUROMUSCULAR DISORDERS
fascicolo: 3, volume: 10, anno: 2000,
pagine: 182 - 186
SICI:
0960-8966(200003)10:3<182:LOACCI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
JEJUNI LIPOPOLYSACCHARIDES; MOLECULAR MIMICRY; ANTIBODIES; NEUROPATHY;
Keywords:
lipopolysaccharides (LPS); Campylobacter coli; Guillain-Barre syndrome; ganglioside antibodies; molecular mimicry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Wirguin, I Ben Gurion Univ Negev, Soroka Med Ctr, Dept Neurol, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 heva, Israel
Citazione:
M. Bersudsky et al., "Lipopolysaccharides of a Campylobacter coli isolate from a patient with Guillain-Barre syndrome display ganglioside mimicry", NEUROMUSC D, 10(3), 2000, pp. 182-186

Abstract

Campylobacter coli was isolated from a patient with severe, axonal type Guillain-Barre syndrome (GBS). The patient's serum was tested by ELISA for glycolipid antibodies and showed a high titer of IgG antibodies to asialo-GM1(GA1) and GD3. Campylobacter coli lipopolysaccharide (LPS) was extracted and analyzed by ELISA, immunoblot binding and blocking studies, and found toavidly bind cholera toxin and peanut agglutinin. The LPS from the patient's isolate also induced anti-GA1 antibodies in a rat model. These findings suggest that the LPS from this bacterial isolate contains a ganglioside-likeepitope. which most likely resembles GA1. Thus, it appears that ganglioside cross-reactivity is not unique to Campylobacter jejuni and seems to occurin all bacterial isolates from GBS cases so far analyzed. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:37:40