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Titolo:
Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease
Autore:
Kaasinen, V; Nagren, K; Hietala, J; Oikonen, V; Vilkman, H; Farde, L; Halldin, C; Rinne, JO;
Indirizzi:
Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Univ Turku, Dept Psychiat, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 pt Psychiat, FIN-20520 Turku, Finland Univ Turku, Dept Pharmacol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 t Pharmacol, FIN-20520 Turku, Finland Turku PET Ctr, Turku, Finland Turku PET Ctr Turku FinlandTurku PET Ctr, Turku, Finland Karolinska Hosp, Dept Clin Neurosci, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 osci, S-10401 Stockholm, Sweden
Titolo Testata:
NEUROLOGY
fascicolo: 7, volume: 54, anno: 2000,
pagine: 1482 - 1487
SICI:
0028-3878(20000411)54:7<1482:EDDADR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 METHYL TRIFLATE; PROGRESSIVE SUPRANUCLEAR PALSY; MESSENGER-RNA EXPRESSION; D-3 RECEPTOR; CAUDATE-NUCLEUS; BASAL GANGLIA; HUMAN-BRAIN; BETA-CIT; PET;
Keywords:
PD; dopamine receptors; D2 subtype; D3 subtype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kaasinen, V Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 FIN-20520 Turku, Finland
Citazione:
V. Kaasinen et al., "Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease", NEUROLOGY, 54(7), 2000, pp. 1482-1487

Abstract

Objective: To investigate whether dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the caudate-putamen are affected in PD. Background: Alterations in striatal D2-like dopamine receptors in PD have been extensively demonstrated using PET, but there are no studies focusing on extrastriatal D2/3Rs. Methods: Fourteen unmedicated patients with idiopathic early PD with predominantly left-sided symptoms, 14 levodopa-medicated patients with advanced PD, and 20 normal age-matched controls were examined using PET. PET scanning was performed with a novel high-affinity D2/3R radioligand ([C-11]FLB 457) and a PET scanner in three-dimensional mode. Results: In advanced PD, the binding potential of [11C]FLB 457 in the dorsolateral prefrontal cortex was decreased by 40% (p < 0.01), in the anterior cingulate cortex by 20% (p< 0.01), and in the medial thalamus by 17% (p < 0.05) compared with healthy controls. In early PD, the extrastriatal [11C]FLB 457 binding potentials were not significantly different compared with the control group. However, the binding potential in the anterior cingulate cortex (29%; p < 0.05) was higher in early PD compared with advanced PD. Conclusions: These results imply that the D2/3 receptor subtypes outside the striatum are affected in advanced PD but not in the early stages of the disease, and that this receptor decline is present in the anterior cingulate cortex, the dorsolateral prefrontal cortex, and the thalamus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:11:44