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Titolo:
Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain
Autore:
Huang, W; Simpson, RK;
Indirizzi:
Baylor Coll Med, Dept Neurosurg, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ept Neurosurg, Houston, TX 77030 USA
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 2, volume: 22, anno: 2000,
pagine: 160 - 164
SICI:
0161-6412(200003)22:2<160:LIAOGP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID ANTAGONISTS; SPINAL-CORD; DORSAL HORN; THERMAL HYPERALGESIA; PERIPHERAL MONONEUROPATHY; RECEPTOR IMMUNOREACTIVITY; CONSTRICTION INJURY; NMDA ANTAGONIST; SCIATIC-NERVE; STRYCHNINE;
Keywords:
hyperalgesia; glycine; neuropathic pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Simpson, RK Baylor Coll Med, Dept Neurosurg, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 77030 USA
Citazione:
W. Huang e R.K. Simpson, "Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain", NEUROL RES, 22(2), 2000, pp. 160-164

Abstract

Neuropathic pain has been postulated to be mediated, in part, by amino acid neurotransmitters including glycine. The current study examined the effects of continuous intrathecal glycine administration (0. 1 mu mol 0.5 mu l(-1) h(-1)) on the development of mechanical hyperalgesia and other features of neuropathic pain evoked by unilateral loose ligation of the sciatic nerve in the rat. Each hind paw was tested for withdrawal threshold to mechanical stimuli prior to, and after ligation at intervals of 3, 6, 9, 12 and 16 days. Pain behavior (posture and gait) and hind paw dystrophic features (redness and swelling) were also examined. Glycine increased the normal mechano-nociceptive responses and prevented the development of mechano-nociceptive hyperalgesia. Spontaneous nociceptive behavior and hind paw dystrophic features, seen in the saline treated rats, were significantly diminished. Ourresults suggest that spinal cord inhibitory glycinergic activity is important for normal mechano-receptive responsitivity and development of mechano-nociceptive hyperalgesia in this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:24:41