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Titolo:
Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection
Autore:
Romiti, ML; Colognesi, C; Cancrini, C; Mas, A; Berrino, M; Salvatori, F; Orlandi, P; Jansson, M; Palomba, E; Plebani, A; Bertran, JM; Hernandez, M; de Martino, M; Amoroso, A; Tovo, PA; Rossi, P; Espanol, T; Scarlatti, G;
Indirizzi:
San Raffaele Sci Inst, DIBIT, Unit Immunobiol HIV, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 biol HIV, I-20132 Milan, Italy Univ Rome Tor Vergata, Childrens Hosp Bambino Gesu, Div Infect Dis & Immunol, Rome, Italy Univ Rome Tor Vergata Rome Italy Div Infect Dis & Immunol, Rome, Italy Inst Salud Carlos III, Madrid, Spain Inst Salud Carlos III Madrid SpainInst Salud Carlos III, Madrid, Spain Molinette Mauriziano Hosp, Transplant Immunol Serv, Turin, Italy MolinetteMauriziano Hosp Turin Italy splant Immunol Serv, Turin, Italy Karolinska Inst, Microbiol & Tumorbiol Ctr, Stockholm, Sweden Karolinska Inst Stockholm Sweden iol & Tumorbiol Ctr, Stockholm, Sweden Univ Turin, Dept Paediat, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Paediat, Turin, Italy Univ Milan, Dept Paediat, Milan, Italy Univ Milan Milan ItalyUniv Milan, Dept Paediat, Milan, Italy CS Vall Hebron, Immunol Unit, Barcelona, Spain CS Vall Hebron Barcelona Spain l Hebron, Immunol Unit, Barcelona, Spain Univ Florence, Dept Pediat, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 ept Pediat, I-50121 Florence, Italy Univ Trieste, Childrens Hosp, Genet Serv, Trieste, Italy Univ Trieste Trieste Italy , Childrens Hosp, Genet Serv, Trieste, Italy
Titolo Testata:
MOLECULAR MEDICINE
fascicolo: 1, volume: 6, anno: 2000,
pagine: 28 - 36
SICI:
1076-1551(200001)6:1<28:PVOACD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; DISEASE PROGRESSION; VIRAL PHENOTYPE; TRANSMISSION; CHILDREN; RECEPTOR; GENE; CCR5-DELTA-32; HETEROZYGOTES; DELETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Scarlatti, G San Raffaele Sci Inst, DIBIT, Unit Immunobiol HIV, Via Olgettina 58, I-20132 Milan, Italy San Raffaele Sci Inst Via Olgettina 58 Milan Italy I-20132 y
Citazione:
M.L. Romiti et al., "Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection", MOL MED, 6(1), 2000, pp. 28-36

Abstract

Background: A deletion of 32 base pairs in the CCR5 gene (Delta 32 CCR5) has been linked to resistance to HIV-1 infection in exposed adults and to the delay of disease progression in infected adults. Materials and Methods: To determine the role of Delta 32 CCR5 in disease progression of HIV-1 infected children born to seropositive mothers, we studied a polymerase chain reaction in 301 HIV-1 infected, 262 HIV-1 exposed-uninfected and 47 HIV-1 unexposed-uninfected children of Spanish and Italian origin. Infected children were further divided into two groups according totheir rate of HIV-1 disease progression: rapid progressors who developed severe clinical and/or immunological conditions within the second year of life, and delayed progressors with any other evolution of disease. Among the latter were the long-term, non-progressors (LTNP) who presented with mild or no symptoms of HIV-1 infection above 8 years of age. Viral phenotype was studied for 45 delayed progressors. Results: No correlation was found between Delta 32 CCR5 and mother-to-child transmission of HIV-1. However, the frequency of the deletion was substantially higher in LTNP, compared with delayed (p = 0.019) and rapid progressors (p = 0.0003). In children carrying the Delta 32 CCR5 mutation, the presence of MT-2 tropic virus isolate was associated with a severe immune suppression (p = 0.028); whereas, the presence of MT-2 negative viruses correlated with LTNP (p = 0.010). Conclusions: Given the rapidity and simplicity of the assay, the Delta 32 CCR5 mutation may be a useful predictive marker to identify children with delayed disease progression who, consequently, may not require immediate antiretroviral treatment.

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Documento generato il 28/11/20 alle ore 04:01:22