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Titolo:
LINE-1 (L1) lineages in the mouse
Autore:
Hardies, SC; Wang, LP; Zhou, LX; Zhao, YP; Casavant, NC; Huang, SJ;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Biochem, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 pt Biochem, San Antonio, TX 78284 USA
Titolo Testata:
MOLECULAR BIOLOGY AND EVOLUTION
fascicolo: 4, volume: 17, anno: 2000,
pagine: 616 - 628
SICI:
0737-4038(200004)17:4<616:L(LITM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUS-SPRETUS; REPEAT FAMILY; GENUS MUS; 5' END; EVOLUTION; RETROTRANSPOSONS; AMPLIFICATION; SEQUENCE; GENOME; SUBFAMILY;
Keywords:
mouse; LINE-1; transposon; horizontal gene transfer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Hardies, SC Univ Texas, Hlth Sci Ctr, Dept Biochem, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 284 USA
Citazione:
S.C. Hardies et al., "LINE-1 (L1) lineages in the mouse", MOL BIOL EV, 17(4), 2000, pp. 616-628

Abstract

Recently, a rapidly amplifying family of mouse LINE-1 (L1) has been identified and named T-F. The evolutionary context surrounding the derivation of the T-F family was examined through phylogenetic analysis of sequences in the 3' portion of the repeat. The Mus musculus domesticus T-F family was found to be the terminal subfamily of the previously identified L1Md4 lineage. The L1Md4 lineage joins the other prototypical mouse LINE-1 lineage (the L1MdA2 lineage) approximately 1 MYA at about the time of the common ancestorof M. m. domesticus, Mus spicilegus, and Mus spretus. However, the T-F family from Al. m. domesticus was found to join to the previously reported M. spretus Ms475 and Ms7024 LINE-1 families at just 0.5 MYA, indicating horizontal transfer. The T-F family from M. m. domesticus was then found to be even more recently related to LINE-1's from another species, Al. spicilegus. A separate spretus A2 lineage was found through a directed search of a PCR library. This lineage, in contrast to the spretus T-F lineage, does join domesticus at about 1 MYA, as would be expected in the absence of horizontal transfer. A third major family was also found that splits off from the L1Md4 lineage shortly after its departure from the L1MdA2 lineage. The new family, named the Z family, was found to contain the de novo LINE-1 inserts causing the beige and riled mutations. Whether the split with the Z family wasbefore or after the recombination that introduced the F-type promoters anddefined the inception of T-F as a lineage is unclear. In enumerating copies of the various LINE-1 families, we found that T-F 3' ends were not much more numerous than the reported number of 5' ends, suggesting that T-F may not be subjected to the 90% truncation pattern typical of LINE-1 as a whole.

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Documento generato il 02/04/20 alle ore 00:18:15