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Titolo:
Coronary artery anomalies and aortic valve morphology in the Syrian hamster
Autore:
Fernandez, MC; Duran, AC; Real, R; Lopez, D; Fernandez, B; de Andres, AV; Arque, JM; Gallego, A; Sans-Coma, V;
Indirizzi:
Univ Malaga, Fac Sci, Dept Biol Anim, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 , Dept Biol Anim, E-29071 Malaga, Spain Max Planck Inst, Dept Expt Cardiol, D-6350 Bad Nauheim, Germany Max PlanckInst Bad Nauheim Germany D-6350 , D-6350 Bad Nauheim, Germany Univ Hosp Carlos Haya, Malaga, Spain Univ Hosp Carlos Haya Malaga SpainUniv Hosp Carlos Haya, Malaga, Spain
Titolo Testata:
LABORATORY ANIMALS
fascicolo: 2, volume: 34, anno: 2000,
pagine: 145 - 154
SICI:
0023-6772(200004)34:2<145:CAAAAV>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL-ANIMALS; NEURAL CREST; ORIGIN; RECOMMENDATIONS; EUTHANASIA; CHICK;
Keywords:
aortic valve; bicuspid aortic valve; coronary arteries; anomalies; heart; Syrian hamster;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez, MC Univ Malaga, Fac Sci, Dept Biol Anim, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 im, E-29071 Malaga, Spain
Citazione:
M.C. Fernandez et al., "Coronary artery anomalies and aortic valve morphology in the Syrian hamster", LAB ANIMALS, 34(2), 2000, pp. 145-154

Abstract

In the Syrian hamster, anomalies in the origin of the left coronary arteryare significantly associated with the bicuspid condition of the aortic valve. In this species, bicuspid aortic valves are expressions of a trait, thevariation of which takes the form of a phenotypic continuum, ranging from a tricuspid aortic valve with no commissural fusion to a bicuspid aortic valve with the aortic sinuses located in ventrodorsal orientation and devoid of any raphe. The intermediate stages of the continuum are represented by tricuspid aortic valves with a more or less extensive fusion of the ventral commissure and bicuspid aortic valves with a more or less developed raphe located in the ventral aortic sinus. The present study was designed to decide whether there is a gap between tricuspid and bicuspid aortic valves regarding the incidence of coronary artery anomalies, or whether this incidence varies according to the different tricuspid and bicuspid morphotypes of thecontinuum. The study was carried out in Syrian hamsters belonging to a Single inbred family with a high incidence of tricuspid aortic valves with fusion of the ventral commissure, bicuspid aortic valves, and anomalies in theorigin of the left coronary artery, i.e. single right coronary artery ostium in aorta, anomalous origin of the left coronary artery from the pulmonary artery, and anomalous origin of the left coronary artery from the dorsal aortic sinus. The specimens were examined by means of a stereomicroscope and, in several cases, scanning electron microscopy was also used. The relationships between anomalous coronary artery patterns and aortic valve morphologies were tested using a logistic regression model. The results obtained indicate that there is no discontinuity between tricuspid and bicuspid aortic valves regarding the incidence of coronary artery anomalies. The probability of occurrence of anomalous coronary artery patterns increases continuously according to the deviation degree of the aortic valve from its normal (tricuspid) design. The present findings suggest that in the Syrian hamster,the morphogenetic mechanisms involved in the formation of congenital anomalous aortic valves and anomalies in the origin of the left coronary artery,respectively, are strongly related from an aetiological viewpoint.

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Documento generato il 25/11/20 alle ore 07:32:24