Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence for viral virulence as a predominant factor limiting human immunodeficiency virus vaccine efficacy
Autore:
Mooij, P; Bogers, WMJM; Oostermeijer, M; Koornstra, W; Ten Haaft, PJF; Verstrepen, BE; Van der Auwera, G; Heeney, JL;
Indirizzi:
Biomed Primate Res Ctr, Dept Virol, NL-2280 GH Rijswijk, Netherlands Biomed Primate Res Ctr Rijswijk Netherlands NL-2280 GH wijk, Netherlands Inst Trop Med, Dept Microbiol, B-2000 Antwerp, Belgium Inst Trop Med Antwerp Belgium B-2000 Microbiol, B-2000 Antwerp, Belgium
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 9, volume: 74, anno: 2000,
pagine: 4017 - 4027
SICI:
0022-538X(200005)74:9<4017:EFVVAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODY-TITERS CORRELATE; RHESUS MACAQUES; ATTENUATED SIV; HIV TYPE-1; NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEINS; CYNOMOLGUS MONKEYS; CHIMERIC VIRUSES; IN-VITRO; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Heeney, JL Biomed Primate Res Ctr, Dept Virol, POB 3306, NL-2280 GH Rijswijk, Netherlands Biomed Primate Res Ctr POB 3306 Rijswijk Netherlands NL-2280 GH
Citazione:
P. Mooij et al., "Evidence for viral virulence as a predominant factor limiting human immunodeficiency virus vaccine efficacy", J VIROLOGY, 74(9), 2000, pp. 4017-4027

Abstract

Current strategies in human immunodeficiency virus type 1 (HIV-1) vaccine development are often based on the production of different vaccine antigensaccording to particular genetic clades of HIV-1 variants. To determine if virus virulence or genetic distance had a greater impact on HIV-1 vaccine efficacy, we designed a series of heterologous chimeric simian/human immunodeficiency virus (SHIV) challenge experiments in HIV I subunit-vaccinated rhesus macaques. Of a total of 22 animals, 10 nonimmunized animals served as controls; the remainder were vaccinated with the CCR5 binding envelope of HIV-1(W6.1D). In the first study, heterologous challenge included two nonpathogenic SHIV chimeras encoding the envelopes of the divergent clade B HIV-1(han2) and HIV-1(sf13) strains. In the second study, all immunized animals were rechallenged with SHIV89.6p, a virus closely related to the vaccine strain but highly virulent. Protection from either of the divergent SHIVsf13 or SHIVhan2 challenges was demonstrated in the majority of the vaccinated animals. In contrast, upon challenge with the more related but virulent SHIV89.6p, protection was achieved in only one of the previously protected vaccinees, A secondary but beneficial effect of immunization on virus load and CD4(+) T-cell counts was observed despite failure to protect from infection. In addition to revealing different levels of protective immunity, these results suggest the importance of developing vaccine strategies capable of protecting from particularly virulent variants of HIV-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:07:30