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Titolo:
HIV-1, cocaine, and neuropsychological performance in African American men
Autore:
Durvasula, RS; Myers, HF; Satz, P; Miller, EN; Morgenstern, H; Richardson, MA; Evans, G; Forney, D;
Indirizzi:
Calif State Univ Los Angeles, Dept Psychol, Los Angeles, CA 90032 USA Calif State Univ Los Angeles Los Angeles CA USA 90032 geles, CA 90032 USA Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA Univ CalifLos Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Charles R Drew Univ Med & Sci, Biobehav Res Ctr, Los Angeles, CA 90059 USACharles R Drew Univ Med & Sci Los Angeles CA USA 90059 eles, CA 90059 USA Charles R Drew Univ Med & Sci, Dept Psychiat, Los Angeles, CA 90059 USA Charles R Drew Univ Med & Sci Los Angeles CA USA 90059 eles, CA 90059 USA Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Med, Dept Psychiat, Boston, MA 02118 USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 3, volume: 6, anno: 2000,
pagine: 322 - 335
SICI:
1355-6177(200003)6:3<322:HCANPI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICENTER AIDS COHORT; IMMUNODEFICIENCY-VIRUS INFECTION; INTRAVENOUS-DRUG-USERS; CHRONIC ALCOHOL-ABUSE; HOMOSEXUAL MEN; BRAIN; ABNORMALITIES; PERFUSION; MANIFESTATIONS; INDIVIDUALS;
Keywords:
HIV infection; cocaine abuse; neuropsychological performance; African American men;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Durvasula, RS Calif State Univ Los Angeles, Dept Psychol, 5151 State Univ Dr, Los Angeles, CA 90032 USA Calif State Univ Los Angeles 5151 State Univ Dr Los Angeles CA USA 90032
Citazione:
R.S. Durvasula et al., "HIV-1, cocaine, and neuropsychological performance in African American men", J INT NEURO, 6(3), 2000, pp. 322-335

Abstract

The purpose of this study was to examine the independent and interactive effects of HPV-I serostatus and cocaine on neuropsychological (NP) performance in a sample of 237 gay and bisexual urban-dwelling African American men. Consistent with current evidence, it was expected that the greatest neuropsychological performance deficits would be evident (1) in the symptomatic seropositives (SSPs), especially in domains affected by MV (i.e., memory andpsychomotor speed), and on tests that are sensitive to subtle slowing; (2)in those who are recent and frequent cocaine abusers; and (3) in those whoare both HIV seropositive and cocaine abusers. Multivariate analyses controlling for age and alcohol use confirmed expectations, with symptomatic seropositives (SSPs) evidencing significantly poorer psychomotor speed than the seronegatives (SNs), and slower reaction time and poorer nonverbal memorythan the asymptomatic seropositives (ASPs). Moderate to heavy recent cocaine use was associated with slower psychomotor speed. However, contrary to expectations, no interaction of serostatus and cocaine was noted for any NP domain, and the expected serostatus and cocaine effects on verbal memory and frontal systems were nor obtained. Level of alcohol consumption exacerbated the detrimental effects of HIV-I on a computerized reaction time test which is especially sensitive to subtle slowing. This study provides one of the first descriptions of the neuropsychological effects of HIV-AIDS in a noninjection drug-using community sample of gay and bisexual African Americanmen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:42:01