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Titolo:
The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development
Autore:
Handwerger, S; Freemark, M;
Indirizzi:
Childrens Hosp, Med Ctr, Div Endocrinol, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 docrinol, Cincinnati, OH 45229 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA l Med, Dept Pediat, Cincinnati, OH USA Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pediat, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Cell Biol, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
fascicolo: 4, volume: 13, anno: 2000,
pagine: 343 - 356
SICI:
0334-018X(200004)13:4<343:TROPGH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN TROPHOBLAST CELLS; MESSENGER-RIBONUCLEIC-ACID; HIGH-DENSITY-LIPOPROTEINS; APOLIPOPROTEIN-A-I; CHORIONIC SOMATOMAMMOTROPIN; PROLACTIN RECEPTOR; INSULIN-LIKE; TRANSCRIPTIONAL REGULATION; PROTEIN-PHOSPHORYLATION; RESPONSE ELEMENT;
Keywords:
fetal growth; placental lactogen; prolactin; growth hormone; placenta; fetal metabolism; gene regulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Handwerger, S Childrens Hosp, Med Ctr, Div Endocrinol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp 3333 Burnet Ave Cincinnati OH USA 45229 9 USA
Citazione:
S. Handwerger e M. Freemark, "The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development", J PED END M, 13(4), 2000, pp. 343-356

Abstract

The human growth hormone (hGH)/human placental lactogen (hPL) gene family,which consists of two GH and three PL genes, is important in the regulation of maternal and fetal metabolism and the growth and development of the fetus. During pregnancy, pituitary GH (hGH-N) expression in the mother is suppressed; and hGH-V, a GH variant expressed by the placenta, becomes the predominant GH in the mother. hPL, which is the product of the hPL-A and hPL-Bgenes, is secreted into both the maternal and fetal circulations after thesixth week of pregnancy. hGH-V and hPL act in concert in the mother to stimulate insulin-like growth factor (IGF) production and modulate intermediary metabolism, resulting in an increase in the availability of glucose and amino acids to the fetus. In the fetus, hPL acts via lactogenic receptors and possibly a unique PL receptor to modulate embryonic development, regulateintermediary metabolism and stimulate the production of IGFs, insulin, adrenocortical hormones and pulmonary surfactant. hGH-N, which is expressed bythe fetal pituitary, has little or no physiological actions in the fetus until late in pregnancy due to the lack of functional GH receptors on fetal tissues. hGH-V, which is also a potent somatogenic hormone, is not releasedinto the fetus. Taken together, studies of the hGH/hPL gene family during pregnancy reveal a complex interaction of the hormones with one another andwith other growth factors. Additional investigations are necessary to clarify the relative roles of the family members in the regulation of fetal growth and development and the factors that modulate the expression of the genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:25:45