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Titolo:
A new algorithm for the quantitation of myocardial perfusion SPECT. II: Validation and diagnostic yield
Autore:
Sharir, T; Germano, G; Waechter, PB; Kavanagh, PB; Areeda, JS; Gerlach, J; Kang, XP; Lewin, HC; Lewin, HC; Berman, DS;
Indirizzi:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA Cedars SinaiMed Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA Cedars SinaiMed Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA Cedars Sinai MedCtr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Cedars Sinai Med Ctr, Burns & Allen Res Inst, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 4, volume: 41, anno: 2000,
pagine: 720 - 727
SICI:
0161-5505(200004)41:4<720:ANAFTQ>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; EMISSION COMPUTED-TOMOGRAPHY; INCREMENTAL PROGNOSTIC VALUE; CLINICAL-DIAGNOSIS; MULTICENTER TRIAL; QUANTIFICATION; STRATIFICATION; PROBABILITY; RISK;
Keywords:
myocardial perfusion quantitation; dual-isotope imaging; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Berman, DS Cedars Sinai Med Ctr, Dept Imaging, 8700 Beverly Blvd,Rm A041, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr 8700 Beverly Blvd,Rm A041 Los Angeles CA USA 90048
Citazione:
T. Sharir et al., "A new algorithm for the quantitation of myocardial perfusion SPECT. II: Validation and diagnostic yield", J NUCL MED, 41(4), 2000, pp. 720-727

Abstract

This study validates a new quantitative perfusion SPECT algorithm for the assessment of myocardial perfusion. The algorithm is not based on slices and provides fully 3-dimensional sampling and analysis independent of assumptions about the geometric shape of the left ventricle, Methods: Radiopharmaceutical- and sex-specific normal limits and thresholds for perfusion abnormality in 20 segments of the left ventricle were developed for separate, dual-isotope rest (TI)-T-201-exercise Tc-99m-sestamibi SPECT in 36 patients with <5% before-scanning likelihood of coronary artery disease (CAD) (group 1) and 159 patients with perfusion abnormalities (group 2). These thresholdswere validated in 131 patients (group 3) by comparison with expert visual interpretation. Thresholds for automatic segmental scores were developed and validated for groups 2 and 3, respectively. The accuracy of CAD detectionwas assessed in 94 patients, who underwent coronary angiography (group 4). Results: Overall sensitivity for detection of stress and rest segmental perfusion abnormality was 91% and 96%, respectively, for men and 89% and 79%,respectively, for women. Overall specificity for stress and rest was 87% and 90%, respectively, for men and 88% and 90%, respectively, for women. Agreement between automatic and visual scores was good (weighted kappa of 0.71and 0.60 for stress and rest images, respectively). Sensitivity and specificity were 88% for the detection of greater than or equal to 70% stenosis. For the detection of left anterior descending, left circumflex, and right coronary artery stenosis, sensitivity was 84%, 86%, and 88%, respectively, and specificity was 84%, 88%, and 81%, respectively. Conclusion: The new quantitative perfusion SPECT approach is highly sensitive and specific for thedetection and localization of CAD, provides accurate automatic scores for the assessment of regional perfusion, and overcomes the low-specificity limitations of previous quantitative algorithms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:23:16