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Titolo:
Binding of [Tc-99m]TRODAT-1 to dopamine transporters in patients with Parkinson's disease and in healthy volunteers
Autore:
Mozley, PD; Schneider, JS; Acton, PD; Plossl, K; Stern, MB; Siderowf, A; Leopold, NA; Li, PY; Alavi, A; Kung, HF;
Indirizzi:
Hosp Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Hosp Univ Penn Philadelphia PA USA 19104 diol, Philadelphia, PA 19104 USA Thomas Jefferson Univ, Parkinsons Res Ctr, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Hosp Univ Penn, Movement Disorders Clin, Philadelphia, PA 19104 USA Hosp Univ Penn Philadelphia PA USA 19104 Clin, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 4, volume: 41, anno: 2000,
pagine: 584 - 589
SICI:
0161-5505(200004)41:4<584:BO[TDT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMAGING AGENTS; TC-99M-LABELED TROPANES; COMPUTED-TOMOGRAPHY; 2 PARTS; TRODAT-1; PET;
Keywords:
normal; movement disorders; SPECT; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mozley, PD Hosp Univ Penn, Dept Radiol, 110 Donner Bldg,3400 Spruce St, Philadelphia,PA 19104 USA Hosp Univ Penn 110 Donner Bldg,3400 Spruce St Philadelphia PA USA 19104
Citazione:
P.D. Mozley et al., "Binding of [Tc-99m]TRODAT-1 to dopamine transporters in patients with Parkinson's disease and in healthy volunteers", J NUCL MED, 41(4), 2000, pp. 584-589

Abstract

[Tc-99m]TRODAT-1 is a radiolabeled tropane that binds dopamine transporters. The primary goal of this study was to determine whether its regional cerebral distribution could differentiate between patients with Parkinson's disease and healthy human volunteers. Methods: The sample consisted of 42 patients with Parkinson's disease, 23 age-matched controls, and 38 healthy adults younger than 40 y old. SPECT scans of the brain were acquired on a triple-head gamma camera 3-4 h after the intravenous injection of 740 MBq (20 mCi) [99mTc]TRODAT-1, Mean counts per pixel were measured manually in subregions of the basal ganglia and normalized to the mean background counts to give specific uptake values ([SUVs] approximate to k3/k4). Patient and control groups were also compared with automated statistical parametric mapping techniques. Logistic discriminant analyses were performed to determine the optimum uptake values for differentiating patients from age-matched controls. Results: Quantitative image analysis showed that the group mean SUVs in patients were less than the mean values in controls for all regions (all Ps< 0.000001). There was overlap in the caudate as well as in the anterior-most portion of the putamen, but not in the posterior putamen, even when theasymptomatic sides of 5 patients with clinically defined hemi-Parkinson's disease were factored in. Conclusion: The findings indicate that Parkinson's disease can be detected with [Tc-99m]TRODAT by simply inspecting the images for uptake in the posterior putamen, Appropriate asymmetries seem to be visible with quantification in patients with clinically defined hemi-Parkinson's disease, even though changes in the putamen contralateral to the clinically unaffected side in these patients appear to precede the development of symptoms,

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Documento generato il 17/01/20 alle ore 20:12:19