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Titolo:
GABAergic inhibition in nucleus magnocellularis: Implications for phase locking in the avian auditory brainstem
Autore:
Monsivais, P; Yang, LC; Rubel, EW;
Indirizzi:
Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 aring Res Ctr, Seattle, WA 98195 USA Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 d & Neck Surg, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 20, anno: 2000,
pagine: 2954 - 2963
SICI:
0270-6474(20000415)20:8<2954:GIINMI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERAURAL TIME DIFFERENCES; ANTEROVENTRAL COCHLEAR NUCLEUS; BARN OWL; NEURAL SYNCHRONIZATION; COINCIDENCE DETECTION; AMPA RECEPTORS; NERVE FIBERS; BUSHY CELLS; STEM; NEURONS;
Keywords:
GABA; nucleus magnocellularis; avian auditory brainstem; phase locking; superior olivary nucleus; K+ conductance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Rubel, EW Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA Univ Washington Box 357923 Seattle WA USA 98195 le, WA 98195 USA
Citazione:
P. Monsivais et al., "GABAergic inhibition in nucleus magnocellularis: Implications for phase locking in the avian auditory brainstem", J NEUROSC, 20(8), 2000, pp. 2954-2963

Abstract

In the avian auditory brainstem, nucleus magnocellularis (NM) functions torelay phase-locked signals to nucleus laminaris for binaural coincidence detection. Although many studies have revealed that NM neurons exhibit intrinsic physiological and anatomical specializations for this purpose, the role of inhibition has not been fully explored. The present study characterizes the organization of GABAergic feedback to NM. Anterograde and retrograde labeling methods showed that NM receives a prominent projection from the ipsilateral superior olivary nucleus (SON). The functional features of this projection were explored in a brain slice preparation. Stimulating fibers from the SON evoked long-lasting, depolarizing responses in NM neurons that were blockable by bicuculline, a GABA(A) receptor antagonist. The slow time course of these responses allowed them to undergo temporal summation duringrepetitive stimulation. The summed GABAergic response was capable of blocking spikes generated in NM neurons by suprathreshold current injection. This inhibitory effect was attributable to a large reduction in input resistance caused by a combination of the opening of a GABAergic Cl- conductance and the recruitment of a low-voltage activated K+ conductance. This large reduction of input resistance increased the amount of current necessary to drive NM neurons to threshold. The results lead us to propose that GABAergic inhibition enhances phase-locking fidelity of NM neurons, which is essentialto binaural coincidence detection in nucleus laminaris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:35:27