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Titolo:
rTLE3, a newly identified transducin-like enhancer of split, is induced bydepolarization in brain
Autore:
Feldman, JD; Vician, L; Crispino, M; Hoe, W; Baudry, M; Herschman, HR;
Indirizzi:
Univ Calif Los Angeles, Ctr Hlth Sci, Inst Mol Biol, Los Angeles, CA 90095USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095USA Univ Calif Los Angeles, Ctr Hlth Sci, Dept Pediat, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Ctr Hlth Sci, Dept Biol Chem, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Ctr Hlth Sci, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA Univ Naples Federico II, Dept Gen & Environm Physiol, Naples, Italy Univ Naples Federico II Naples Italy & Environm Physiol, Naples, Italy
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 5, volume: 74, anno: 2000,
pagine: 1838 - 1847
SICI:
0022-3042(200005)74:5<1838:RANITE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; REPRESENTATIONAL DIFFERENCE ANALYSIS; GROUCHO-RELATED GENE; PC12 PHEOCHROMOCYTOMA CELLS; MESSENGER-RNA EXPRESSION; DROSOPHILA-ENHANCER; KAINIC ACID; EARLY NEUROGENESIS; SEIZURE ACTIVITY; BETA-SUBUNIT;
Keywords:
transducin-like enhancers of split; gene expression; depolarization; kainic acid; PC12 cells; representational difference analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Herschman, HR Univ Calif Los Angeles, Ctr Hlth Sci, Inst Mol Biol, Boyer Hall,611 Charles E Young Dr E, Los Angeles, CA 90095 USA Univ Calif Los Angeles Boyer Hall,611 Charles E Young Dr E Los Angeles CA USA 90095
Citazione:
J.D. Feldman et al., "rTLE3, a newly identified transducin-like enhancer of split, is induced bydepolarization in brain", J NEUROCHEM, 74(5), 2000, pp. 1838-1847

Abstract

The transducin-like enhancers of split are a family of mammalian proteins that share sequence homology with the Drosophila protein Groucho, Using representational difference analysis, we isolated the cDNA for a previously unidentified gene, rTLE3 (rat transducin-like enhancer of split 3), as a sequence induced by depolarization and forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. rTLE3 encodes the protein rTLE3, a 764-amino acid orthologue of mouse and human TLE3. R-esp2, the gene encoding the closest related rat protein, is not induced by any of the fourtreatments in PC12 cells. rTLE3 and R-esp2 have different patterns of expression in the adult rat CNS and other tissues. After systemic administration of kainic acid, rTLE3 is induced specifically in the dentate gyrus of thehippocampus. We propose that members of the transducin-like enhancer of split family of proteins may have distinct functions in the mature CNS, in addition to their functions during development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:40:12