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Titolo:
The chiral separation of oxybutynin enantiomers using an ovomucoid column
Autore:
Walker, TA;
Indirizzi:
Geneva Pharmaceut Inc, Analyt Dev, Broomfield, CO 80038 USA Geneva Pharmaceut Inc Broomfield CO USA 80038 v, Broomfield, CO 80038 USA
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 6, volume: 23, anno: 2000,
pagine: 841 - 853
SICI:
1082-6076(2000)23:6<841:TCSOOE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ALPHA(1)-ACID GLYCOPROTEIN COLUMN; BONDED STATIONARY PHASE; HUMAN SERUM-ALBUMIN; ALPHA-1-ACID GLYCOPROTEIN; OPTICAL RESOLUTION; RETENTION MECHANISMS; DRUG ENANTIOMERS; PH; STEREOISOMERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, TA Geneva Pharmaceut Inc, Analyt Dev, 2655 W Midway Blvd,POB 446, Broomfield,CO 80038 USA Geneva Pharmaceut Inc 2655 W Midway Blvd,POB 446 Broomfield CO USA 80038
Citazione:
T.A. Walker, "The chiral separation of oxybutynin enantiomers using an ovomucoid column", J LIQ CHR R, 23(6), 2000, pp. 841-853

Abstract

The separation of oxybutynin enantiomers (racemic mixture of two enantiomers) was studied on an ovomucoid column. The optimized chiral separation baseline resolved the enantiomers in less than 10 minutes. Chromatographic variables that were found to have an effect on the chiral separation were studied and include: mobile phase pH, mobile phase ionic strength, type and concentration of organic modifier added to the mobile phase, column temperature, and the amount of analyte injected. The enantiomeric separation was optimized on the ovomucoid column based onhow each variable affected the separation. Calibration curves for a standard were linear over a range of 8.36 to 668.8 mu g/g (ppm) with a correlation coefficient of 0.999 for both enantiomers. A detection limit of 4.5 mu g/g and a quantitation limit of 9.0 mu g/g were also found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:10:43