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Titolo:
Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy
Autore:
Illes, Z; Kondo, T; Newcombe, J; Oka, N; Tabira, T; Yamamura, T;
Indirizzi:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Immunol, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat Kodaira Tokyo Japan 1878502 kyo 1878502, Japan Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat Kodaira Tokyo Japan 1878502 kyo 1878502, Japan Inst Neurol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG nst Neurol, London WC1N 3BG, England Kyoto Univ, Fac Med, Dept Neurol, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 Univ, Fac Med, Dept Neurol, Kyoto 606, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 8, volume: 164, anno: 2000,
pagine: 4375 - 4381
SICI:
0022-1767(20000415)164:8<4375:DEONTC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE REDUCTION; ANTIGEN RECEPTOR; BONE-MARROW; MICE; RECOGNITION; ACTIVATION; ANTI-CD3; GAMMA; IL-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamura, T Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Immunol, 4-1-1 Ogawahigashi, Kodaira, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat 4-1-1 Ogawahigashi Kodaira Tokyo Japan 1878502
Citazione:
Z. Illes et al., "Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy", J IMMUNOL, 164(8), 2000, pp. 4375-4381

Abstract

Human V alpha 24(+) NK T cells are a unique subset of lymphocytes expressing the V alpha 24J alpha Q invariant TCR chain. Because they can rapidly produce large amounts of regulatory cytokines, a reduction of NK T cells may lead to the development of certain autoimmune diseases. Using a single-strand conformation polymorphism method, we demonstrate that a great reduction of V alpha 24J alpha Q NK T cells in the peripheral blood is an immunological hallmark of multiple sclerosis, whereas it is not appreciable in other autoimmune/inflammatory diseases such as chronic inflammatory demyelinating polyneuropathy, The chronic inflammatory demyelinating polyneuropathy lesions were often found to be infiltrated with V alpha 24J alpha Q NK T cells, but multiple sclerosis lesions only rarely expressed the V alpha 24J alpha Q TCR. It is therefore possible that the extent of NK T cell alteration maybe a critical factor which would define the clinical and pathological features of autoimmune disease. Although the mechanism underlying the NK T celldeletion remains largely unclear, a remarkable contrast between the CNS and peripheral nervous system diseases allows us to speculate a role of tissue-specific elements such as the level of CD1d expression or differences in the CD1d-bound glycolipid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:03:14