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Titolo:
Presentation of alpha B-crystallin to T cells in active multiple sclerosislesions: An early event following inflammatory demyelination
Autore:
Bajramovic, JJ; Plomp, AC; van der Goes, A; Koevoets, C; Newcombe, J; Cuzner, ML; van Noort, JM;
Indirizzi:
TNO Prevent & Hlth, Div Immunol & Infect Dis, NL-2301 CE Leiden, Netherlands TNO Prevent & Hlth Leiden Netherlands NL-2301 CE CE Leiden, Netherlands Free Univ Amsterdam, Fac Med, Dept Cell Biol & Immunol, Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands munol, Amsterdam, Netherlands Univ Coll London, Dept Neurochem, Inst Neurol, London, England Univ Coll London London England Neurochem, Inst Neurol, London, England
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 8, volume: 164, anno: 2000,
pagine: 4359 - 4366
SICI:
0022-1767(20000415)164:8<4359:POABTT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; HEAT-SHOCK PROTEIN; MICROGLIAL CELLS; EXPRESSION; MACROPHAGES; PATHOGENESIS; AUTOIMMUNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: van Noort, JM TNO Prevent & Hlth, Div Immunol & Infect Dis, POB 2215, NL-2301 CE Leiden,Netherlands TNO Prevent & Hlth POB 2215 Leiden Netherlands NL-2301 CE s
Citazione:
J.J. Bajramovic et al., "Presentation of alpha B-crystallin to T cells in active multiple sclerosislesions: An early event following inflammatory demyelination", J IMMUNOL, 164(8), 2000, pp. 4359-4366

Abstract

In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step, Previously, alpha B-crystallin has been shown to be an important myelin Ag to human T cells. Since alpha B-crystallin is an intracellular heat shock protein, the question arises at what stage, if any, during lesional development in MS this Ag becomes available for CD4(+) T cells, In 3 of 10 active MS lesions, alpha B-crystallin could be detected inside phagocytic vesicles of perivascular macrophages, colocalizing with myelin basic protein and myelin oligodendrocyte glycoprotein (MOG), Although the detectability of MOG in phagosomes is considered as a marker for very recent demyelination, MOG was detected in more macrophages and in more lesions than alpha B-crystallin. Thedisappearance of alpha B-crystallin from macrophages even before MOG was confirmed by in vitro studies; within 6 h after myelin-uptake alpha B-crystallin disappears from the phagosomes. alpha B-Crystallin-containing macrophages colocalized with infiltrating T cells and they were characterized by expression of MHC class II, CD40, and CD80, To examine functional presentation of myelin Ags to T cells, purified macrophages were pulsed in vitro with whole myelin membranes. These macrophages activated both myelin-primed and alpha B-crystallin-primed T cells in terms of proliferation and IFN-gamma secretion, In addition, alpha B-crystallin-pulsed macrophages activated myelin-primed T cells to the same extent as myelin-pulsed macrophages, whereas myelin basic protein-pulsed macrophages triggered no response at all. Thesedata indicate that, in active MS lesions, alpha B-crystallin is available for functional presentation to T cells early during inflammatory demyelination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:33:07