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Titolo:
CD134L engagement enhances human B cell Ig production: CD154/CD40, CD70/CD27, and CD134/CD134L interactions coordinately regulate T cell-dependent B cell responses
Autore:
Morimoto, S; Kanno, Y; Tanaka, Y; Tokano, Y; Hashimoto, H; Jacquot, S; Morimoto, C; Schlossman, SF; Yagita, H; Okumura, K; Kobata, T;
Indirizzi:
Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 unol, Mibu, Tochigi 3210293, Japan Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 v, Sch Med, Dept Immunol, Tokyo 113, Japan Juntendo Univ, Sch Med, Dept Rheumatol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 Sch Med, Dept Rheumatol, Tokyo 113, Japan Univ Ryukyus, Fac Med, Okinawa Asia Res Ctr Med Sci, Okinawa, Japan Univ Ryukyus Okinawa Japan Okinawa Asia Res Ctr Med Sci, Okinawa, Japan Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Tokyo, Japan Japan Sci & Technol Corp Tokyo Japan Evolut Sci & Technol, Tokyo, Japan Dana Farber Canc Inst, Div Tumor Immunol, Boston, MA 02115 USA Dana FarberCanc Inst Boston MA USA 02115 r Immunol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 8, volume: 164, anno: 2000,
pagine: 4097 - 4104
SICI:
0022-1767(20000415)164:8<4097:CEEHBC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD40 LIGAND; OX40 LIGAND; HYPER-IGM; ACTIVATION MOLECULE; SOLUBLE FORM; IN-VIVO; DIFFERENTIATION; EXPRESSION; ANTIGEN; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kobata, T Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan Dokkyo Univ 880 Kitakobayashi Mibu TochigiJapan 3210293 , Japan
Citazione:
S. Morimoto et al., "CD134L engagement enhances human B cell Ig production: CD154/CD40, CD70/CD27, and CD134/CD134L interactions coordinately regulate T cell-dependent B cell responses", J IMMUNOL, 164(8), 2000, pp. 4097-4104

Abstract

CD134 is a member of the TNFR family expressed on activated T cells, whoseligand, CD134L, is found preferentially on activated B cells. We have previously reported that the CD70/CD27 interaction may be more important in theinduction of plasma cell differentiation after the expansion phase inducedby the CD154/CD40 interaction has occurred, When CD134-transfected cells were added to PBMCs stimulated with pokeweed mitogen, IgG production was enhanced in a dose-dependent fashion. Addition of CD134-transfected cells to Bcells stimulated with Staphylococcus aureus Cowan I strain/IL-2 resulted in little if any enhancement of B cell IgG production and proliferation. We found that while CD134-transfected cells induced no IgG production by themselves, it greatly enhanced IgG production in the presence of CD40 stimulation or T cell, cytokines such as IL-4 and IL-10. The addition of CD134-transfected cells showed only a slight increase in the number of plasma cells compared with that in the culture without them, indicating that an increased Ig production rate per cell is responsible for the observed enhancing effect of CD134L engagement rather than increase in plasma cell generation. These results strongly suggest different and sequential roles of the TNF/TNFR family molecules in human T cell-dependent B cell responses through cell-cell contacts and the cytokine network.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:57:39