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Titolo:
Long-term topical timolol and blood lipids: The Blue Mountains Eye Study
Autore:
Mitchell, P; Wang, JJ; Cumming, RG; House, P; England, JDF;
Indirizzi:
Univ Sydney, Dept Ophthalmol, Westmead, NSW 2145, Australia Univ Sydney Westmead NSW Australia 2145 ol, Westmead, NSW 2145, Australia Univ Sydney, Dept Publ Hlth & Community Med, Westmead, NSW 2145, AustraliaUniv Sydney Westmead NSW Australia 2145 ed, Westmead, NSW 2145, Australia Royal Perth Hosp, Dept Ophthalmol, Perth, WA, Australia Royal Perth Hosp Perth WA Australia ept Ophthalmol, Perth, WA, Australia Australia Blue Mt Dist Hosp, Katoomba, NSW, Australia Australia Blue Mt Dist Hosp Katoomba NSW Australia oomba, NSW, Australia
Titolo Testata:
JOURNAL OF GLAUCOMA
fascicolo: 2, volume: 9, anno: 2000,
pagine: 174 - 178
SICI:
1057-0829(200004)9:2<174:LTTABL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; CHOLESTEROL LEVEL; OCULAR CARTEOLOL; SERUM-LIPIDS; PLASMA; AUSTRALIA; MECHANISMS; PREVALENCE; METABOLISM; GLAUCOMA;
Keywords:
beta-blocker; glaucoma; lipids; timolol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Mitchell, P Univ Sydney, Dept Ophthalmol, Hawkesbury Rd, Westmead, NSW 2145, Australia Univ Sydney Hawkesbury Rd Westmead NSW Australia 2145 ustralia
Citazione:
P. Mitchell et al., "Long-term topical timolol and blood lipids: The Blue Mountains Eye Study", J GLAUCOMA, 9(2), 2000, pp. 174-178

Abstract

Objectives: To examine whether an association exists between long-term useof topical timolol and blood lipids, including high-density lipoprotein cholesterol (HDL-C), cholesterol and triglycerides, among participants of theBlue Mountains Eye Study. Methods: From 1992 through 1994. a detailed medical and eye examination was performed in 3.654 people aged 49 years or older: representing 82% of permanent residents in two postcode areas west of Sydney. Glaucoma and ocular hypertension were diagnosed. and an ophthalmic history was taken, includinguse of topical timolol. Fasting blood tests were performed in 89% of subjects. Lipid levels were compared in subjects using topical timolol for at least 1 year with those not using timolol, after excluding people using oral beta-blockers, topical beta-selective agents, or oral lipid-lowering medications. Results: Analyses compared blood lipids of 63 people who had used topical timolol for at least 1 year with 2,597 nonusers. No statistically significant differences were found in any blood lipid mean levels between treated and untreated people, after multivariate adjustment. However, subgroup analyses of men and women separately showed that male timolol users had a mean value of HDL-C 0.13 mmol/L (11%) lower then the mean value of male nonusers, while female timolol users had a mean value of HDL-C 0.09 mmol/L (5%) higher than the mean for female nonusers. Then were no statistically significantassociations between timolol treatment duration and HDL-C or other lipid levels. Previously reported adverse effects of oral beta-blockers on blood lipid levels were confirmed. Conclusions: These population-based data suggest that long-term administration of topical timolol for glaucoma or ocular hypertension can cause adverse effects on HDL-C in men, but not in women. The magnitude of the effect in men was similar to that previously described in a number of short-term studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 08:02:24