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Titolo:
Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgGautoantibodies
Autore:
Ehrenstein, MR; Cook, HT; Neuberger, MS;
Indirizzi:
MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH , Mol Biol Lab, Cambridge CB2 2QH, England Univ Coll London, Dept Med, London W1P 9PG, England Univ Coll London London England W1P 9PG ept Med, London W1P 9PG, England Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Histopathol, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 7, volume: 191, anno: 2000,
pagine: 1253 - 1257
SICI:
0022-1007(20000403)191:7<1253:DISI(P>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL ACTIVATION; MICE; LIPOPOLYSACCHARIDE; AUTOIMMUNITY; COMPLEMENT; NEPHRITIS;
Keywords:
immunodeficiency; autoimmunity; B lymphocyte; secretory IgM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Neuberger, MS MRC, Mol Biol Lab, Hills Rd, Cambridge CB2 2QH, England MRC Hills Rd Cambridge England CB2 2QH dge CB2 2QH, England
Citazione:
M.R. Ehrenstein et al., "Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgGautoantibodies", J EXP MED, 191(7), 2000, pp. 1253-1257

Abstract

Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have: an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented antiDNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to sell-a paradoxical association reminiscent of that described in humans deficient in complement or IgA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:46:40