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Titolo:
Genetics of rat hypodactyly
Autore:
Krenova, D; Jirsova, Z; Bila, V; Kasparek, R; Pravenec, M; Kren, V;
Indirizzi:
Charles Univ, Fac Med 1, Inst Biol & Med Genet, Prague 12800 2, Czech Republic Charles Univ Prague Czech Republic 12800 2 rague 12800 2, Czech Republic Charles Univ, Fac Med 1, Inst Histol & Embryol, Prague 12800 2, Czech Republic Charles Univ Prague Czech Republic 12800 2 rague 12800 2, Czech Republic Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic Acad Sci CzechRepubl Prague Czech Republic iol, Prague, Czech Republic
Titolo Testata:
JOURNAL OF EXPERIMENTAL ANIMAL SCIENCE
fascicolo: 1-2, volume: 41, anno: 2000,
pagine: 47 - 50
SICI:
0939-8600(200003)41:1-2<47:GORH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Keywords:
rat hypodactyly; chromosome 10; male sterility; disorder of spermatogenesis; Hd-congenic strains;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Kren, V Charles Univ, Fac Med 1, Inst Biol & Med Genet, Albertov 4, Prague12800 2, Czech Republic Charles Univ Albertov 4 Prague Czech Republic 12800 2 ch Republic
Citazione:
D. Krenova et al., "Genetics of rat hypodactyly", J EXP ANIM, 41(1-2), 2000, pp. 47-50

Abstract

Rat hypodactyly was originally described by MOUTIER et al. (1973) as an autosomal recessive trait. The determining gene Hd has been recently mapped to rat chromosome 10 and is closely linked to the D10Rnt31/32, D10Rat30, andMyh3 loci (KRENOVA et al. 1998). In homozygous state (Hd/Hd), there is a variable reduction in the number of fingers and metacarpals - metatarsals offront and hind feet in males and females. Moreover, there is a male sterility in homozygotes whereas male heterozygotes are fertile. The light and electron microscopic examination confirmed disorder of spermatogenesis, loosening and vacuolization of seminiferous epithelium accompanied with a significantly decreased number of germ cells in testes of homozygotes. In an intercross population (Wistar HdxBN-Lx)F2, an independent segregation of the major genes Lx, coding for the PLS (polydactyly-luxate syndrome), and Hd - hypodactyly was found together with irregular interactions of Hd and Lx genes in double homozygotes (Hd/Hd, Lx/Lx). The variable phenotype manifestation of foot malformation in double homozygous animals indicated modifying influences of genes of the genetic background. In order to study more precisely the role of the determining major gene Hd as well as the role of the putative modifying genes in the development of the foot malformation and male sterility, we started the production of two congenic strains by introgressing the Hd mutant gene onto the genetic backgrounds of the BN and SHR inbred strains.

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Documento generato il 04/04/20 alle ore 12:21:03