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Titolo:
Preganglionic and postganglionic neurons responsible for cerebral vasodilation mediated by nitric oxide in anesthetized dogs
Autore:
Toda, N; Ayajiki, K; Tanaka, T; Okamura, T;
Indirizzi:
Shiga Univ Med Sci, Dept Pharmacol, Ohtsu, Shiga 5202192, Japan Shiga UnivMed Sci Ohtsu Shiga Japan 5202192 Ohtsu, Shiga 5202192, Japan
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 4, volume: 20, anno: 2000,
pagine: 700 - 708
SICI:
0271-678X(200004)20:4<700:PAPNRF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASILAR ARTERIAL CONSTRICTION; BLOOD-FLOW; NERVE FUNCTION; NITROXIDERGIC NERVE; INDUCED RELAXATION; INHIBITION; MONKEY; TONE; RAT; ACETYLCHOLINE;
Keywords:
nitric oxide; cerebral vasodilation; pterygopalatine ganglion; greater superficial petrosal nerve; parasympathetic innervation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Toda, N Shiga Univ Med Sci, Dept Pharmacol, Ohtsu, Shiga 5202192, Japan Shiga Univ Med Sci Ohtsu Shiga Japan 5202192 Shiga 5202192, Japan
Citazione:
N. Toda et al., "Preganglionic and postganglionic neurons responsible for cerebral vasodilation mediated by nitric oxide in anesthetized dogs", J CEREBR B, 20(4), 2000, pp. 700-708

Abstract

The authors performed investigations to functionally determine the route of efferent innervation in vivo responsible for cerebral vasodilation mediated by nitric oxide (NO). In anesthetized beagles, electrical stimulation ofthe pterygopalatine ganglion vasodilated ipsilateral cerebral arteries such as the middle cerebral and posterior communicating arteries. Intravenous injections of NO-nitro-L-arginine (L-NA) markedly inhibited the response tonerve stimulation, and the effect was reversed by L-arginine. Stimulation of the proximal portion of the greater superficial petrosal nerve, upstreamof the pterygopalatine ganglion, also produced cerebral vasodilation, which was abolished by L-NA and restored by L-arginine. Treatment with hexamethonium abolished the response to stimulation of the petrosal nerve but did not affect the response to pterygopalatine ganglion stimulation. Destructionof the pterygopalatine ganglion by cauterization constricted the cerebral arteries. Post-ganglionic denervation abolished the vasodilation, lacrimation, and nasal secretion induced on the ipsilateral side by stimulation of the pterygopalatine ganglion and petrosal nerve. The vasodilator response was suppressed by L-NA but unaffected by atropine, whereas lacrimation and nasal secretion were abolished solely by atropine. It is concluded that postganglionic neurons from the pterygopalatine ganglion play crucial roles in cerebral vasodilation mediated by NO from the nerve, and pre ganglionic neurons, possibly from the superior salivatory nucleus through the greater superficial petrosal nerve, innervate the pterygopalatine ganglion. Tonic discharges from the vasomotor center participate significantly in the maintenance of cerebral vasodilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:10:19