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Titolo:
Expression of p16(INK4A) and alterations of the 9p21-23 chromosome region in non-small-cell lung carcinomas: Relationship with tumor growth parameters and ploidy status
Autore:
Mariatos, G; Gorgoulis, VG; Zacharatos, P; Kotsinas, A; Vogiatzi, T; Rassidakis, G; Foukas, P; Liloglou, T; Tiniakos, D; Angelou, N; Manolis, EN; Veslemes, M; Field, JK; Kittas, C;
Indirizzi:
Univ Athens, Sch Med, Dept Histol & Embryol, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 ol & Embryol, GR-10679 Athens, Greece Roy Castle Int Ctr Lung Canc Res, Liverpool, Merseyside, England Roy Castle Int Ctr Lung Canc Res Liverpool Merseyside England e, England Univ Athens, Sotiria Hosp, Dept Pulm Med, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 ept Pulm Med, GR-10679 Athens, Greece
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 2, volume: 89, anno: 2000,
pagine: 133 - 141
SICI:
0020-7136(20000320)89:2<133:EOPAAO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATIVE ACTIVITY; NUCLEAR ANTIGEN; RB PROTEIN; CANCER; P53; KI-67; LOCUS; DELETION; PATHWAY; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gorgoulis, VG Antaiou 53 Str Lamprini,Ano Patissia, GR-11146 Athens, Greece Antaiou 53 Str Lamprini,Ano Patissia Athens Greece GR-11146
Citazione:
G. Mariatos et al., "Expression of p16(INK4A) and alterations of the 9p21-23 chromosome region in non-small-cell lung carcinomas: Relationship with tumor growth parameters and ploidy status", INT J CANC, 89(2), 2000, pp. 133-141

Abstract

The 9p21-23 chromosome region harbors a number of known and putative tumor-suppressor genes (TSGs). The best characterized gene in this area is p16(INK4A) (CDKN2A). Alterations of its product have been observed in various malignancies, including non-small-cell lung carcinomas (NSCLCs). We earlier investigated the mechanisms underlying p16(INK4A) inactivation. In the present study, we examined, in a series of 87 NSCLCs, its relationship with the kinetic parameters [proliferation index (PI) and apoptotic index (AI)] and the ploidy status of the tumors. In addition, we extended our previous LOH analysis of the 9p21-23 region by examining flanking areas of p16(INK4A). Aberrant p16 expression was observed in 41.4% of the carcinomas. A significant association was found with increased PI (p = 0.037), but not with apoptosis. Aneuploid tumors were more frequently correlated with abnormal p16 staining (p = 0.05), A high frequency of allelic imbalance (AIm) was noticed at: the D9S161 (51.3%) and D9S157 (64.5%) loci, which lie approximately 4cM centromeric and 7cM telomeric, respectively, to CDKN2A, Abnormal p16(INK4A)expression was strongly correlated with Aim at D9S161 (p = 0.004). Alleliclosses at D9S157 occurred more frequently in early stages (p = 0.018) and were significantly associated with deletions at D9S161 (p = 0.035). We conclude that, in a sub-set of NSCLCs, (i) abnormal p16 expression contributes to tumor growth mainly by increasing the proliferative activity in the initial stages of carcinogenesis; (ii) the association with aneuploidy merely reflects the impact of aberrant p16 on proliferative activity; and (iii) other putative TSGs possibly reside within the 9p21-23 region that possibly co-operate in certain cases with CDKN2A in the development of NSCLCs. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:57:03