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Titolo:
Peroral immunotheraphy with yolk antibodies for the prevention and treatment of enteric infections
Autore:
Carlander, D; Kollberg, H; Wejaker, PE; Larsson, A;
Indirizzi:
Univ Uppsala Hosp, Dept Med Sci, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 ed Sci, S-75185 Uppsala, Sweden Childrens Univ Hosp, Dept Pediat, S-75185 Uppsala, Sweden Childrens Univ Hosp Uppsala Sweden S-75185 diat, S-75185 Uppsala, Sweden
Titolo Testata:
IMMUNOLOGIC RESEARCH
fascicolo: 1, volume: 21, anno: 2000,
pagine: 1 - 6
SICI:
0257-277X(2000)21:1<1:PIWYAF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHICKEN EGG-YOLK; BIRTH-WEIGHT INFANTS; PASSIVE-IMMUNIZATION; BOVINE ROTAVIRUS; NEONATAL CALVES; GASTROINTESTINAL-TRACT; STREPTOCOCCUS-MUTANS; INDUCED DIARRHEA; IMMUNOGLOBULINS; IGY;
Keywords:
antibody; chicken; egg; immunoglobulin; yolk; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Larsson, A Univ Uppsala Hosp, Dept Med Sci, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 5185 Uppsala, Sweden
Citazione:
D. Carlander et al., "Peroral immunotheraphy with yolk antibodies for the prevention and treatment of enteric infections", IMMUNOL RES, 21(1), 2000, pp. 1-6

Abstract

Oral administration of specific antibodies is an attractive approach to establish protective immunity against gastrointestinal pathogens in humans and animals. The increasing number of antibiotic-resistant bacteria emphasizethe need to find alternatives to antibiotics. Immunotherapy can also be used against pathogens that are difficult to neat with traditional antibiotics. Laying hens are very good producers of specific antibodies. After immunization, the specific antibodies are transported to the egg yolk from which the antibodies then can be purified. A laying hen produces more than 20 g of yolk antibodies (IgY) per year. These antibodies also have biochemical properties that make them attractive for peroral immunotherapy: They neither activate mammalian complement nor interact with mammalian Fc receptors that could mediate inflammatory response in the gastrointestinal tract. Eggs are also normal dietary components and thus there is practically no risk of toxic side effects of IgY. Yolk antibodies have been shown in several studies to prevent bacterial and viral infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:02:30