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Titolo:
The metabolic effect of antenatal corticosteroid therapy
Autore:
Ogueh, O; Johnson, MR;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Sch Med, Sect Obstet & Gynaecol, London SW10 9NH, England Univ London Imperial Coll Sci Technol & Med London England SW10 9NH land
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 2, volume: 6, anno: 2000,
pagine: 169 - 176
SICI:
1355-4786(200003/04)6:2<169:TMEOAC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; FACTOR-BINDING PROTEIN-1; GROWTH-FACTOR IGF; CORTICOTROPIN-RELEASING HORMONE; BIRTH-WEIGHT INFANTS; DEXAMETHASONE TREATMENT; POSTNATAL-DEVELOPMENT; SERUM OSTEOCALCIN; CARBOXYTERMINAL PROPEPTIDE; GLUCOCORTICOID TREATMENT;
Keywords:
antenatal corticosteroids; dexamethasone; fetal growth; metabolic effects; respiratory distress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, MR Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Sch Med, Sect Obstet & Gynaecol, 369 Fulham Rd, London SW10 9NH,England Univ London Imperial Coll Sci Technol & Med 369 Fulham Rd London England SW10 9NH
Citazione:
O. Ogueh e M.R. Johnson, "The metabolic effect of antenatal corticosteroid therapy", HUM REP UPD, 6(2), 2000, pp. 169-176

Abstract

The use of antenatal dexamethasone to mature the fetal lung in pregnancieslikely to deliver before 34 weeks is almost universal, It reduces the incidence of respiratory distress syndrome in the newborn and results in an overall improvement in neonatal morbidity and mortality. Although considered to be generally safe, there are concerns about adverse maternal and fetal effects. In a series of studies, we have found that antenatal dexamethasone administration is associated with reduced placental hormone production and maternal bone formation, impaired glucose tolerance and altered function of the hypothalamic-pituitary-adrenal axis. In this article, we have compared our data with other reports in the human and reviewed the relevant animal data. We conclude that further studies on the long-term effects of antenataldexamethasone therapy in the human are warranted with particular emphasis on the long-term effects on the fetus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:22:10