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Titolo:
Activities of Na+,K+-ATPase and Ca2+-ATPase in cochlear lateral wall afteracoustic trauma
Autore:
Hsu, CJ; Shau, WY; Chen, YS; Liu, T; Lin-Shiau, SY;
Indirizzi:
Natl Taiwan Univ, Coll Med, Dept Otolaryngol, Taipei, Taiwan Natl Taiwan Univ Taipei Taiwan ll Med, Dept Otolaryngol, Taipei, Taiwan Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan Natl Taiwan Univ Taipei Taiwan 10764 nst Epidemiol, Taipei 10764, Taiwan Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei 10764, Taiwan Natl Taiwan Univ Taipei Taiwan 10764 nst Pharmacol, Taipei 10764, Taiwan
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 142, anno: 2000,
pagine: 203 - 211
SICI:
0378-5955(200004)142:1-2<203:AONACI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERIAL-SECTION RECONSTRUCTION; QUIET-AGED GERBILS; GUINEA-PIG COCHLEA; INNER-EAR; STRIA VASCULARIS; ATPASE ACTIVITY; ULTRASTRUCTURAL-CHANGES; NA,K-ATPASE ACTIVITY; STEREOCILIA DAMAGE; HYPERTENSIVE RATS;
Keywords:
Na+,K+-ATPase; Ca2+-ATPase; microcolorimetric assay; noise-induced hearing loss;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hsu, CJ Natl Taiwan Univ, Coll Med, Dept Otolaryngol, 7 Chung Shan S Rd, Taipei, Taiwan Natl Taiwan Univ 7 Chung Shan S Rd Taipei Taiwan Taipei, Taiwan
Citazione:
C.J. Hsu et al., "Activities of Na+,K+-ATPase and Ca2+-ATPase in cochlear lateral wall afteracoustic trauma", HEARING RES, 142(1-2), 2000, pp. 203-211

Abstract

Na+,K+-ATPase and Ca2+-ATPase are well known participants in the active transport of ions in the inner ear. These two enzymes play an important role in maintaining cochlear function. Although changes in these enzymes' activities in the cochlea have been implicated in noise-induced hearing loss, no evidence of quantitative alteration of Na+,K+-ATPase or Ca2+-ATPase activities has ever been shown. The present study was undertaken to determine the quantitative alterations of their activities by microcolorimetric assay in the cochlear lateral wall after acoustic trauma. Adult albino guinea pigs were exposed to white noise at 105 +/- 2 dB A for 10 min or 40 h. The age-matched control animals were not exposed to noise. Noise exposure resulted ina significant threshold shift of the auditory brainstem response (P < 0.001). Significant decreases in activities of Na+,K+-ATPase and Ca2+-ATPase were found in the cochlear lateral wall after noise exposure (P < 0.001). Statistical analysis indicated that a good correlation held not only between the decline of these enzyme activities and noise-induced hearing loss, but also between the gradual partial recovery of these parameters during the first 10-day recovery period. The present findings suggest that metabolic damage and ionic disturbance may contribute, at least partially, to noise-induced hearing threshold shift. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:07:47