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Titolo:
Glial cell line-derived neurotrophic factor has a dose dependent influenceon noise-induced hearing loss in the guinea pig cochlea
Autore:
Shoji, F; Yamasoba, T; Magal, E; Dolan, DF; Altschuler, RA; Miller, JM;
Indirizzi:
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ng Res Inst, Ann Arbor, MI 48109 USA Tohoku Univ, Sch Med, Dept Otolaryngol, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 tolaryngol, Sendai, Miyagi 980, Japan Univ Tokyo, Dept Otolaryngol, Bunkyo Ku, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 Dept Otolaryngol, Bunkyo Ku, Tokyo 113, Japan Amgen Inc, Dept Neurosci, Thousand Oaks, CA 91320 USA Amgen Inc Thousand Oaks CA USA 91320 eurosci, Thousand Oaks, CA 91320 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 142, anno: 2000,
pagine: 41 - 55
SICI:
0378-5955(200004)142:1-2<41:GCLNFH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; GDNF MESSENGER-RNA; NEURONS IN-VITRO; HAIR-CELLS; INNER-EAR; AUDITORY NEURONS; GROWTH-FACTOR; DOPAMINERGIC-NEURONS; GANGLION NEURONS; FACTOR PROTECTS;
Keywords:
cochlea; HC; GDNF; neurotrophic factor; osmotic pump; noise-induced hearing loss;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, JM Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109USA Univ Michigan 1301 E Ann St Ann Arbor MI USA 48109 MI 48109USA
Citazione:
F. Shoji et al., "Glial cell line-derived neurotrophic factor has a dose dependent influenceon noise-induced hearing loss in the guinea pig cochlea", HEARING RES, 142(1-2), 2000, pp. 41-55

Abstract

We examined the effectiveness of glial cell line-derived neurotrophic factor (GDNF) to attenuate cochlear damage from intense noise stress. Subjects were exposed to 115 dB SPL one octave band noise centered at 4 kHz for 5 h. They received artificial perilymph with or without GDNF into the left scala tympani at 0.5 mu l/h from 4 days before noise exposure through 8 days following noise exposure. Different concentrations of GDNF (1 ng/ml, 10 ng/ml, 100 ng/ml, and 1 ng/ml) were applied chronically directly into the guineapig cochlea via a microcannula and osmotic pump.:Noise-induced hearing loss was assessed with pure tone auditory brainstem responses (at 2, 4, 8 and 20 kHz), measured, prior to surgery, 1 day before noise exposure, and 7 days following noise exposure. Subjects were killed on day 8 following exposure for histological preparation and quantitative assessment of hair cell (HC) damage. A dose-dependent protective effect of GDNF on both sensory cell preservation and hearing function was found in the treated ears. At 1 ng/ml,GDNF showed no significant protection; at 10 ng/ml, GDNF showed significant HC protection; and at 100ng/ml, it was greater and bilateral. At 1 mu g/ml, GDNF appeared to have a toxic effect under noise stress in some cochleae. These findings indicate that GDNF at certain concentrations can effectively protect the inner ear from noise-induced hearing loss. (C) 2000 ElsevierScience B.V. All rights reserved.

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Documento generato il 05/12/20 alle ore 14:19:04